Surgical Management of Craniopharyngiomas from 1976 to 1992: Problems and Results



Although Northfield’s opinion of 1957 that: “the treatment of these (craniopharyngioma) patients is fraught with difficulty and disappointment to a degree probably not offered by any other intracranial tumor with exception of glioblastoma” nowadays sounds unacceptably pessimistic, craniopharyngioma surgery is still a major challenge, even for experienced neurosurgeons, and many consider it one of the most delicate intracranial procedures (Baskin and Wilson 1986; Cushing 1932; Hoffman et al. 1992; Katz 1975; Manaka et al. 1985).


Tumor Removal Tumor Remnant Secondary Surgery Tumor Regrowth Complete Tumor Removal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Adamson TE, Wiestler OD, Kleihues P, et al (1990) Correlation of clinical and pathological features in surgically treated craniopharyngiomas. J Neurosurg 73:12–17PubMedCrossRefGoogle Scholar
  2. Backlund EO (1973) Studies on craniopharyngiomas. III. Stereotaxic treatment with intracystic yttrium-90. Acta Chir Scand 139:237–247PubMedGoogle Scholar
  3. Backlund EO, Johansson L, Sorby B (1972) Studies on craniopharyngiomas. II. Treatment by stereotaxis and radiosurgery. Acta Chir Scand 138:749–759PubMedGoogle Scholar
  4. Baskin DS, Wilson CB (1986). Surgical management of craniopharyngiomas. J Neurosurg 65:22–27PubMedCrossRefGoogle Scholar
  5. Cavazzuti V, Fisher EG, Welch K, et al (1983) Neurological and psychophysiological sequelae following different treatment of craniopharyngiomas in children. J Neurosurg 59:409–417PubMedCrossRefGoogle Scholar
  6. Cushing HW (1932) Intracranial tumors. Notes upon a series of two thousand verified cases with surgical mortality percentages pertaining theretho. Thomas, Springfield, p 97Google Scholar
  7. Fisher EG, Welch K, Belli JA, et al (1985) Treatment of craniopharyngiomas in cmidren: 1972–1981. J Neurosurg 62:496–501CrossRefGoogle Scholar
  8. Galatzen A, Nofar E, Halachm BN, et al (1981) Intellectual and psychosocial functions of children, adolescents and young adults before and after operation for craniopharyngiomas. Child Care Health Dev 7:307–316CrossRefGoogle Scholar
  9. Grant DB, Lyen K (1982) Hypopitituarism after surgery for craniopharyngioma. Child Brain 9:201–204Google Scholar
  10. Hoffman HJ, Hendrick EB, Humphreys RP, et al (1977) Management of craniopharyngiomas in children. J Neurosurg 47:218–227PubMedCrossRefGoogle Scholar
  11. Hoffman HJ, De Silva M, Humphreys RP (1992) Aggressive surgical management of craniopharyngiomas in children. J Neurosurg 76:47–52PubMedCrossRefGoogle Scholar
  12. Kahn EA, Gosh HH, Seeger JF, et al (1973) Forty-five years experience with craniopharyngiomas. Surg Neurol 1:5–12PubMedGoogle Scholar
  13. Katz EL (1975) Late results of radical excision of craniopharyngiomas in children. J Neurosurg 42:86–90PubMedCrossRefGoogle Scholar
  14. Kramer S (1976) Craniopharyngiomas: the best treatment is conservative surgery and postoperative radiation therapy. In: Marley TP (ed) Current controversies in neurosurgery. Saunders, Philadelphia, pp 336–343Google Scholar
  15. Kramer S, McKissock W, Coucannon JP (1961) Craniopharyngiomas. Treatment Dy combined surgery and radiation therapy. J Neurosurg 18:217–226PubMedCrossRefGoogle Scholar
  16. Kramer S, Southard H, Hansfield C (1968) Radiotherapy in the management of craniopharyngiomas: further experiences and late results. Am J Roentgenol Radium Ther Nucl Med 103:44–52PubMedCrossRefGoogle Scholar
  17. Lapras C, Palet JD, Mattolise C, et al (1987) Craniopharyngiomas in childhood. Analysis of 42 cases. Progr Exp Tumor Res 30:350–358PubMedGoogle Scholar
  18. Manaka S, Teramoto A, Takakura K (1985) The efficacy of radiotherapy for craniopharyngiomas. J Neurosurg 62:648–656PubMedCrossRefGoogle Scholar
  19. Matson DD (ed) (1969) Neurosurgery of infancy and childhood, 2nd edn. Thomas, SpringfieldGoogle Scholar
  20. Matson D.D, Cligler JF Jr (1969) Management of craniopharyngiomas in childhood. J Neurosurg 27:52–79Google Scholar
  21. McMurry FG, Hardy RW, Donh DF, et al (1977) Longterm results in the management of craniopharyngiomas. Neurosurgery 1:238–241PubMedCrossRefGoogle Scholar
  22. Musolino A, Munari C, Blond S, et al (1985) Traitement stereotaxique des cystes expansifs de craniopharyngiomes pour irradiation endocavitaire Beta (Re 186; Au 198; Y 90). Neurochirurgie 31:69–178Google Scholar
  23. Northfield DWC (1957) Rathke-pouch tumors. Brain 80:293–312PubMedCrossRefGoogle Scholar
  24. Pollack IF, Lunsford LD, Slamovits TL (1988) Stereotaxic intracavitary irradiation for cystic craniopharyngiomas. J Neurosurg 68:227–233PubMedCrossRefGoogle Scholar
  25. Sweet WH (1976) Radical surgical treatment of craniopharyngiomas. Clin Neurosurg 27:52–79Google Scholar
  26. Symon L, Sprich W (1985) Radical excision of craniopharyngiomas: results in 20 patients. J Neurosurg 62:174–181PubMedCrossRefGoogle Scholar
  27. Yasargil MG, Curcic M, Kis M, et al (1990) Total removal of craniopharyngiomas. Approaches and long term results in 144 patients. J Neurosurg 73:3–11PubMedCrossRefGoogle Scholar
  28. Youl BD, Plant GT, Steven JH, et al (1990) Three cases of craniopharyngiomas showing optic tract hypersignal on MRI. Neurology 40:1416–1419PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 1995

Authors and Affiliations

  1. 1.Ospedale Maggiore, Policlinico, IRCCS, Institute of NeurosurgeryUniversity of MilanMilanItaly
  2. 2.Ospedale San RaffaeleUniversity of MilanMilanItaly

Personalised recommendations