Long QT Syndrome: from Molecular Biology to Clinical Management
The last few years have witnessed a dramatic progress in the molecular biology of the congenital long QT syndrome (LQTS). The impact of these discoveries on the understanding of LQTS, and also of other diseases in which control of the cardiac action potential is important, has been recently reviewed by a multidisciplinary task force . This progress has largely resulted from the partnership between molecular biologists and the clinical investigators who had made available the extraordinarily large number of LQTS families with a very well characterized phenotype enrolled in the International Registry co-ordinated by Moss and Schwartz.
KeywordsHeart Rate Increase Ventricular Repolarization Cardiac Action Potential Cardiac Sodium Channel LQT3 Patient
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