Have MADIT and Recent Post Myocardial Infarction Amiodarone Studies Changed the Classical Indications for ICD Implantation?

  • S. H. Hohnloser
  • F. Bogun


Sudden cardiac death still accounts for approximately 200 000 to 400 000 premature deaths in the USA [1] and thus continues to be a major challenge in today’s cardiology. Within the last 12 months, several well controlled prospective studies have been published concerning the value of prophylactic implantation of the cardioverter-defibrillator (ICD) [2] and the administration of amiodarone to improve survival of patients after myocardial infarction [3, 4]. For the practicing cardiologist and even more so for the electrophysiologist, these trials pose the question whether one of these studies, taken alone or combined, impact on current indications for the implantation of the ICD. Therefore, it is the purpose of this short review to summarize the main findings of these major trials and put them into perspective with respect to our current therapy aiming at preventing sudden cardiac death.


Heart Rate Variability Sudden Cardiac Death Implantable Cardioverter Defibrillator Arrhythmic Death Antiarrhythmic Versus Implantable Defibrillator 
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Copyright information

© Springer-Verlag Italia 1998

Authors and Affiliations

  • S. H. Hohnloser
    • 1
  • F. Bogun
    • 1
  1. 1.Dept. of CardiologyJ.W. Goethe UniversityFrankfurtGermany

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