Abstract
CTEPH is the result of single or recurrent pulmonary thromboemboli arising from sites of venous thrombosis. The natural history of pulmonary thromboemboli is to undergo total resolution, or resolution leaving minimal residua, with restoration of normal pulmonary haemodynamics. For reasons still unclear, thromboemboli in CTEPH patients fail to resolve and form endothelialised obstructions of the pulmonary vascular bed including the major branches.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Moser KM, Auger WR, Fedullo PF (1990) Chronic major-vessel thromboembolic pulmonary hypertension. Circulation 81: 1735 - 1743
Moser KM, Bloor CM (1993) Pulmonary vascular lesions occurring in patients with chronic major vessel thromboembolic pulmonary hypertension. Chest 103: 685 - 692
Blanchard DG, Dittrich HC (1992) Pericardial adaptation in severe chronic pulmonary hypertension. An intraoperative transesophageal echocardiographic study. Circulation 85: 1414-1422
Dittrich HC, Chow LC, Nicod PH (1989) Early improvement in left ventricular diastolic function after relief of chronic right ventricular pressure overload. Circulation 80: 823 - 830
Olman MA, Marsh JJ, Lang IM et al (1992) Endogenous fibrinolytic system in chronic large-vessel thromboembolic pulmonary hypertension. Circulation 86: 1241 - 1248
Martinuzzo ME, Pombo G, Forastiero RR et al (1998) Lupus anticoagulant, high levels of anticardiolipin, and anti-beta2-glycoprotein I antibodies are associated with chronic thromboembolic pulmonary hypertension [In Process Citation]. J Rheumatol 25: 1313 - 1319
Auger WR, Permpikul P, Moser KM (1995) Lupus anticoagulant, heparin use, and thrombocytopenia in patients with chronic thromboembolic pulmonary hypertension: a preliminary report. Am J Med 99: 392 - 396
Lang IM, Klepetko W, Pabinger I (1996) No increased prevalence of the factor V Leiden mutation in chronic major vessel thromboembolic pulmonary hypertension ( CTEPH) [letter]. Thromb Haemost 76: 476-477
Lang IM, Marsh JJ, Olman MA et al (1994) Expression of type 1 plasminogen activator inhibitor in chronic pulmonary thromboemboli. Circulation 89: 2715 - 2721
Lang IM, Moser KM, Schleef RR (1996) Expression of Kunitz protease inhibitor-containing forms of amyloid beta-protein precursor within vascular thrombi. Circulation 94: 2728 - 2734
Moser KM, Fedullo PF, Finkbeiner WE, Golden J (1995) Do patients with primary pulmonary hypertension develop extensive central thrombi? Circulation 91: 741 - 745
Kerr KM, Auger WR, Fedullo PF et al (1995) Large vessel pulmonary arteritis mimicking chronic thromboembolic disease. Am J Respir Crit Care Med 152: 367 - 373
Morris TA, Auger WR, Ysrael MZ et al (1996) Parenchymal scarring is associated with restrictive spirometric defects in patients with chronic thromboembolic pulmonary hypertension. Chest 110: 399 - 403
Olman MA, Auger WR, Fedullo PF, Moser KM (1990) Pulmonary vascular steal in chronic thromboembolic pulmonary hypertension. Chest 98: 1430 - 1434
Jamieson SW (1998) Pulmonary thromboendarterectomy [editorial]. Heart 79: 118 - 120
Iversen S (1994) Surgical treatment of thromboembolism-induced pulmonary hypertension. Z Kardiol 6: 193 - 199
Klepetko W, Moritz A, Burghuber OC et al (1995) Chronic thromboembolic pulmonary hypertension and its treatment with pulmonary thrombendarterectomy. Wien KIM Wochenschr 107: 396 - 402
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer-Verlag Italia
About this paper
Cite this paper
Lang, I., Kneussl, M. (2000). Focus on Pathophysiology, Diagnosis and Management of Chronic Thromboembolic Disease. In: Gullo, A. (eds) Anesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2286-7_6
Download citation
DOI: https://doi.org/10.1007/978-88-470-2286-7_6
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0095-7
Online ISBN: 978-88-470-2286-7
eBook Packages: Springer Book Archive