Cellular Mechanisms of Brain Damage
In recent years, the great advance in the area of genetics and cellular and molecular neurobiology has led neuroscientists to attempt to discover the cellular and molecular basis of neurological diseases. A neurological disease can be caused by a defective gene, an environmental insult, or by the interaction between environmental factors and preexisting genetic abnormalities. The mechanisms by which cell damage or dysfunction occurs in the nervous system are multiple and related to the nature of the pathological agents. Nevertheless some general mechanisms leading to cell death can be activated independently of the pathological agents. In this review some cellular and molecular mechanisms of brain damage will be focused on, looking at the unifying routes of neuronal cell death.
KeywordsAmyotrophic Lateral Sclerosis Nerve Growth Factor Motor Neuron Disease Brain Damage Familial Amyotrophic Lateral Sclerosis
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- 3.Dingledine R, McBain CJ (1999) Glutamate and aspartate. In: Siegel GJ, Agranoff BW, Albers WR et al (ed) Basic neurochemistry. Lippincott-Raven, Philadelphia New York, pp 315–333Google Scholar
- 5.Choi DW (1996) Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 6: 1261–1276Google Scholar
- 12.Davis SW, Turmaine M, Cozens BA et al (1997) Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation Cell 90: 537–548Google Scholar
- 15.Mulder DW, Kurland LT, Offord KP, Beard CM (1986) Familial adult motor neuron disease: Amyotrophie lateral sclerosis. Neurology 36: 511–517Google Scholar