Cellular Mechanisms of Brain Damage

  • G. Savettieri
  • I. Di Liegro
  • A. Cestelli


In recent years, the great advance in the area of genetics and cellular and molecular neurobiology has led neuroscientists to attempt to discover the cellular and molecular basis of neurological diseases. A neurological disease can be caused by a defective gene, an environmental insult, or by the interaction between environmental factors and preexisting genetic abnormalities. The mechanisms by which cell damage or dysfunction occurs in the nervous system are multiple and related to the nature of the pathological agents. Nevertheless some general mechanisms leading to cell death can be activated independently of the pathological agents. In this review some cellular and molecular mechanisms of brain damage will be focused on, looking at the unifying routes of neuronal cell death.


Amyotrophic Lateral Sclerosis Nerve Growth Factor Motor Neuron Disease Brain Damage Familial Amyotrophic Lateral Sclerosis 
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© Springer-Verlag Italia 2000

Authors and Affiliations

  • G. Savettieri
  • I. Di Liegro
  • A. Cestelli

There are no affiliations available

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