Beta Blockers and General Anesthesia: Prevention of Myocardial Ischemia

  • R. Muchada
Conference paper


The prevention of myocardial ischemia should be one of the main objectives during anesthesia [1]. If we define the myocardial ischemia as the rupture of the balance between the transport of O2 (DO2) and the local metabolic needs, two different types can be identified:
  • absolute ischemia, following the total absence of perfusion. This situation leads to irreversible cellular alterations. All preventive actions are, in this case, impracticable;

  • relative ischemia, for DO2 that is inadequate but sufficient to maintain temporary cellular viability. It is a high-risk situation which must be recognized and treated very fast. The causative mechanism frequently involved is tachycardia, generally determined by an adrenergic discharge with beta-1 positive effects.


Myocardial Ischemia Beta Blocker Systolic Time Interval Diastolic Arterial Blood Pressure Relative Ischemia 
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© Springer-Verlag Italia 2000

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  • R. Muchada

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