Working Mechanisms of Anaesthetic Agents
These words were the opening of Hans Meyer’s lecture dealing with the working mechanism of anaesthetic agents, at the Harvey Society on 7th October 1905. The words were, at that time, as relevant as they are now. Many are still attracted by this problem and, indeed, with all the progress that is made in biochemistry, biophysics as well as cell biology this problem still presents a great challenge. Nevertheless, since the formulation of first theories on anaesthetic action in the Middle Ages (or perhaps antiquity), much improvement on theoretical ground has been achieved. This is specially true for the intravenous anaesthetics [1, 21 but less obvious for the volatile anaesthetic drugs. The working mechanism of volatile anaesthetics is still a topic of extensive research that is build upon a long history of thinking about neuronal function.
KeywordsAnaesthetic Agent Volatile Anaesthetic Minimum Alveolar Concentration Anaesthetic Effect Anaesthetic Action
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