Ischaemia-Reperfusion in Sepsis

  • C. Adembri
  • A. R. De Gaudio
  • G. P. Novelli
Conference paper


It has been over 20 years since Hearse described the “oxygen paradox” and the “calcium paradox” in hearts undergoing ischaemia-reperfusion (I-R) [1]. The concept that it is reperfusion itself that increases and potentiates ischaemia-induced damage has progressively gained ground, and it is now one of the main factors taken into account in the treatment of various pathological states, from crush injury to transplantation [2, 3] . Even when reperfusion itself is the goal of therapy, such as during thrombolysis for infarcted myocardium, reperfusion-associated dysfunctions, which range from arrhythmias to stunning, must be considered as they significantly affect morbidity and mortality rates [4, 5]. Regardless of the cause and the modality that have provoked it, the sequence of ischaemia and reperfusion actually induces a typical inflammatory response which is not restricted to the injured tissue but frequently has a systemic recoil [6].


Nitric Oxide Multiple Organ Failure Bacterial Translocation Human Skeletal Muscle Xanthine Dehydrogenase 
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Copyright information

© Springer-Verlag Italia 2000

Authors and Affiliations

  • C. Adembri
  • A. R. De Gaudio
  • G. P. Novelli

There are no affiliations available

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