A Paradigm Shift: The Bidirectional Effect of Inflammation on Bacterial Growth

  • G. U. Meduri
Conference paper


The ability to generate and respond to signaling molecules establishes a mechanism for regulated cell-to-cell communication. Cells coordinate their growth and proliferation with autocrine and paracrine signaling by means of low molecular weight polypeptides called cytokines. Innate or natural immunity is a highly conserved defense mechanism against infections found in all multicellular organisms [1]. The inflammatory reaction is a fundamental component of the innate immune response, and its most proximal expression is characterized by the elaboration of proinflammatory cytokines — tumor necrosis factor (TNF)-α and interleukin (IL)-1β. Response to cytokines is generally viewed as exclusive to cells containing a defined nucleus, since cytokines are intended to work on welldefined eukaryotic cells with consequent signal transduction events.


Acute Respiratory Distress Syndrome Nosocomial Infection Respir Crit Multiple Organ Dysfunction Syndrome Mycobacterium Avium 
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© Springer-Verlag Italia 2000

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  • G. U. Meduri

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