Are There Useful New Markers of Sepsis?

  • M. Meisner
  • K. Reinhart
Conference paper


Severe infections and sepsis are common causes of morbidity and mortality in intensive care units. Clinical and laboratory signs of systemic inflammation such as changes in body temperature, leukocytosis, and tachycardia are frequently used for the diagnosis of infection or sepsis [1]. However, these signs and symptoms are neither specific nor sensitive for infection or sepsis. Various other and non-microbial infection related aetiologies of systemic inflammation may induce these symptoms. For example, patients suffering from pancreatitis, major trauma or burns present with a similar inflammatory response even in the absence of infectious complications. On the other hand, bacteriological evidence of infection, though definitive and specific, may not develop concurrently with clinical signs of sepsis.


Septic Shock Severe Sepsis Systemic Inflammation Adult Respiratory Distress Syndrome Viral Meningitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Italia 2000

Authors and Affiliations

  • M. Meisner
  • K. Reinhart

There are no affiliations available

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