Abstract
Liver dysfunction is commonly associated with critical illness. Up to 54% of patients admitted to intensive care units present abnormal liver function tests. Severe liver dysfunction is reported to occur in 12–95% of adult respiratory distress syndrome patients and liver blood tests on the first day of diagnosis are predictive of survival [1]. Liver failure is a critical determinant of mortality in trauma [2], in intra-abdominal sepsis [2], and after cardiopulmonary bypass surgery [3].
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References
Schwartz DB, Bone RC, Balk RA et al (1989) Hepatic dysfunction in the adult respiratory distress syndrome. Chest 95:871–875
Te Boekhorst T, Urlus M, Doesburg W et al (1988) Etiologic factors of jaundice in severely ill patients. J Hepatol 7:111–117
Collins JD, Bassendine MF, Ferner R et al (1983) Incidence and prognostic importance of jaundice after cardiopulmonary bypass surgery. Lancet i:1119–1123
Garvin IP (1837) Remarks on pneumonia biliosa. S Med and Surg 1:536–544
Ayuse T, Brienza N, O’Donnell CP et al (1995) Alterations in liver hemodynamics in an intact porcine model of endotoxin shock. Am J Physiol 268 H 1106–H 1114
Dahn M, Lange P, Lobdell K et al (1987) Splanchnic and total body oxygen consumption differences in septic and injured patients. Surgery 101:69–80
Brienza N, Ayuse T, Revelly JP et al (1995) Effects of endotoxin on the isolated porcine liver: Pressure-flow analysis. J Appl Physiol 78:784–792
Brienza N, Ayuse T, Revelly JP et al (1998) Peripheral control of venous return in critical illness: role of the splanchnic vascular compartment. In: Dantzker DR, Scharf SM (eds) Cardiopulmonary critical care. Saunders, Philadelphia, pp 93–114
Pannen BHJ, Bauer M, Zhang JX et al (1996) A time-dependent balance between endothelins and nitric oxide regulating portal resistance after endotoxin pretreatment. Am J Physiol 271: H1953–H1961
Clemens MG, Bauer M, Gingalewski C et al (1994) Hepatic intercellular communication in shock and inflammation. Shock 2:1–9
Watanabe Y, Puschel GP, Gardemann A et al (1994) Presinusoidal and proximal intrasinusoidal confluence of hepatic artery and portal vein in rat liver: Functional evidence by orthograde and retrograde bivascular perfusion. Hepatology 19:1198–1207
Schywalsky M, Metzger HP (1990) Redistribution of local hepatic blood flow during acute bleeding and prolonged hemorrhagic hypotension studied using fluorochromed plasma proteins and surface PO>2 measurements In: Piiper J (ed) Oxygen transport to tissue. Plenum Press, New York, pp 697–703
Clemens MG, Mc Donagh PF, Chaundry IH et al (1985) Hepatic microcirculatory failure following ischemia and reperfusion: Improvement with ATP-MgCI2 treatment. Am J Physiol 248:H804–H811
Ghezzi P, Saccardo B, Villa P et al (1986) Role of interleukin-1 in the depression of liver drug metabolism by endotoxin. Infect Immun 54:837–840
Hawker F (1991) Liver dysfunction in critical illness. Anaesth Intens Care 19:165–181
Matuschak GM, Rinaldo JE (1988) Organ interactions in the adult respiratory distress syndrome during sepsis. Role of the liver in host defense. Chest 94:400–406
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© 2000 Springer-Verlag Italia
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Brienza, N. (2000). Pathophysiology of Liver Dysfunction in Sepsis. In: Baue, A.E., Berlot, G., Gullo, A., Vincent, JL. (eds) Sepsis and Organ Dysfunction. Springer, Milano. https://doi.org/10.1007/978-88-470-2284-3_11
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DOI: https://doi.org/10.1007/978-88-470-2284-3_11
Publisher Name: Springer, Milano
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