The kidney is a significant target organ for the sepsis syndrome and, depending on the definitions used, acute renal failure (ARF) occurs in as many as 15% of patients with critical illness  and sepsis appears to be a contributing factor in as many as 43 % . In addition, the kidney is usually the organ that fails first . While the mortality rate of isolated acute renal failure is approximately 10 to 15%, ARF in the setting of sepsis carries a mortality rate between 50 to 90% according to published series. In a recent study , the mortality rate among 253 cases of ARF treated in the ICU was 71.5% whereas it was 31.5% among the 495 cases of ARF treated in a non-ICU setting (p = 0.001).
KeywordsAcute Renal Failure Mean Arterial Pressure Renal Injury Renal Blood Flow Renal Vascular Resistance
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