The Kidney in Sepsis

  • J. A. Kellum
Conference paper


The kidney is a significant target organ for the sepsis syndrome and, depending on the definitions used, acute renal failure (ARF) occurs in as many as 15% of patients with critical illness [1] and sepsis appears to be a contributing factor in as many as 43 %[2] . In addition, the kidney is usually the organ that fails first [3]. While the mortality rate of isolated acute renal failure is approximately 10 to 15%, ARF in the setting of sepsis carries a mortality rate between 50 to 90% according to published series. In a recent study [4], the mortality rate among 253 cases of ARF treated in the ICU was 71.5% whereas it was 31.5% among the 495 cases of ARF treated in a non-ICU setting (p = 0.001).


Acute Renal Failure Mean Arterial Pressure Renal Injury Renal Blood Flow Renal Vascular Resistance 
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© Springer-Verlag Italia 2000

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  • J. A. Kellum

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