Epidemiology and management of sepsis in neonates

  • B. Urlesberger
  • B. Resch
  • E. Gradnitzer
  • W. Müller
Part of the Topics in Anaesthesia and Critical Care book series (TIACC)


The term neonatal sepsis refers to invasive bacterial infections that involve primarily the bloodstream in infants during the first month of life. As a “compromised host” the neonate does not localize infections well. Two patterns of disease have been associated with systemic bacterial infections: early-onset and late-onset sepsis. Early-onset disease presents as a fulminant, multisystemic illness within the first 96 h of life; it is associated with a high mortality rate (15%–50%). Whereas late-onset sepsis, occurring later than 4 days of postnatal age, usually presents as a slowly progressive illness with focal infection (most often meningitis), it is associated with a lower mortality rate (10%–20%) [1]. Some organisms, such as Escherichia coli, group B Streptococcus, and Listeria monocytogenes, may be responsible for both early-onset and late-onset sepsis, whereas others, such as Staphylococcus aureus and Pseudomonas aeruginosa, are usually only associated with late-onset disease.


Neonatal Sepsis Neonatal Infection Meconium Aspiration Syndrome Invasive Bacterial Infection Serum Tumor Necrosis Factor 
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Copyright information

© Springer-Verlag Italia 1999

Authors and Affiliations

  • B. Urlesberger
  • B. Resch
  • E. Gradnitzer
  • W. Müller

There are no affiliations available

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