Open-Label Before-After Trials of Anti-Chlamydia pneumoniae Antibiotics in Asthma

  • D. L. Hahn


At the time of writing, no randomized, controlled trials of anti-chlamydial antibiotics directed against asthma have been published. Such trials are underway, or are being planned, based upon (1) reported seroepidemiologic associations linking chlamydial infection to asthma (see the chapter,“Chlamydia pneumoniae: A New Possible Cause of Asthma”) and (2) published case reports [1, 2] and case series [3–5] indicating favorable results of open-label antibiotic administration to patients with asthma who also had culture-confirmed infection, seroreactivity, or both.


Asthma Symptom Macrolide Antibiotic Chlamydial Infection Reactive Airway Disease Microbiologic Eradication 
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    Kawane H (1993) Chlamydia pneumoniae. Thorax 48: 871PubMedCrossRefGoogle Scholar
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    Hahn DL (1994) Infection as a cause of asthma. Ann Allergy 73: 276PubMedGoogle Scholar
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    Hahn DL (1995) Treatment of Chlamydia pneumoniae infection in adult asthma: a before-after trial. J Fam Pract 141: 345–351Google Scholar
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    Emre U, Roblin PM, Gelling M et al (1994) The association of Chlamydia pneumoniae infection and reactive airway disease in children. Arch Pediatr Adolesc Med 148: 727–732PubMedCrossRefGoogle Scholar
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    Hahn D, Bukstein D, Luskin A et al (1998) Evidence for Chlamydia pneumoniae infection in steroid-dependent asthma. Ann Allergy Asthma Immunol 80: 45–49PubMedCrossRefGoogle Scholar

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© Springer-Verlag Italia, Milano 1999

Authors and Affiliations

  • D. L. Hahn

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