Antibiotic Treatment in Atherosclerosis and Myocardial Infarction

  • S. Gupta
  • J. C. Kaski


Evidence is accumulating to suggest that Chlamydia pneumoniae may have a role in the development and/or progression of atherosclerotic-related disorders, in particular coronary heart disease (CHD). The evidence for C. pneumoniae as a potential causative agent is largely based on the findings of (1) seroepidemiological studies, (2) examination of atheromatous plaque specimens, (3) in vitro experiments and animal models and, recently, (4) preliminary anti-chlamydial antibiotic intervention studies. This chapter aims at focusing on the potential, and intriguing, role of antimicrobial therapy in the secondary prevention of CHD. The findings of the preliminary pilot studies are reviewed, as are the aims and controversies surrounding large-scale, prospective intervention trials, now in progress.


Coronary Heart Disease Antibody Titre Chlamydial Infection Prevalent Coronary Heart Disease Coronary Endarterectomy 
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© Springer-Verlag Italia, Milano 1999

Authors and Affiliations

  • S. Gupta
  • J. C. Kaski

There are no affiliations available

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