Abstract
The cumulative seroepidemiologic studies, direct detection of Chlamydia pneumoniae antigen in atherosclerotic lesions throughout the arterial tree, and culturing of the organism from atheromatous tissue provide compelling evidence for an association of C. pneumoniae with atherosclerosis [1]. However, these findings do not establish causality, which can only be proven through the use of animal models or intervention studies. This chapter will focus on animal models of C. pneumoniae and their use in studying pathogenesis, intervention strategies for eradication of acute and chronic infection, and putative roles of C. pneumoniae infection on atherogenesis. The recent establishment of mouse and rabbit models of C. pneumoniae infection that also are well-defined experimental models of atherosclerosis has provided the opportunity to address the hypothesis that C. pneumoniae infection affects the onset, severity, or progression of atherosclerosis.
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References
Grayston JT, Kuo C-C, Campbell LA, Wang S-P, Jackson L (1997) Chlamydia pneumoniae and cardiovascular disease. Cardiologia 42: 1145–1151
Yang Z-P, Kuo C-C, Grayston JT (1993) A mouse model of Chlamydia pneumoniae strain TWAR pneumonitis. Infect Immun 61: 2037–2040
Kaukoranta-Tolvanen SS, Laurila AL, Saikku P, Leinonen M, Liesirova L, Laitinen K (1993) Experimental infection of Chlamydia pneumoniae in mice. Microb Pathog 15: 293–302
Yang Z-P, Cummings PK, Patton DL, Kuo C-C (1995) Ultrastructural lung pathology of experimental Chlamydia pneumoniae pneumonitis in mice. J Infect Dis 171: 736–738
Moazed TC, Kuo C-C, Grayston JT, Campbell LA (1996) An experimental rabbit model of Chlamydia pneumoniae infection. Am J Pathol 148: 667–676
Bell TA, Kuo C-C, Wang S-P, Grayston JT (1989) Experimental infection of baboons (Papio cynocephalus anubis) with Chlamydia pneumoniae strain “TWAR.” J Infect 29: 47–49
Holland SM, Taylor HR, Gaydos CA, Kappus EW, Quinn TC (1990) Experimental infection with Chlamydia pneumoniae in nonhuman primates. Infect Immun 58: 593–597
Moazed TC, Kuo C-C, Grayston JT, Campbell LA (1997) Murine models of Chlamydia pneumoniae infection and atherosclerosis. J Infect Dis 175: 883–890
Malinverni R, Kuo C-C, Campbell LA, Grayston JT (1995) Reactivation of Chlamydia pneumoniae lung infection in mice by cortisone. J Infect Dis 172: 593–594
Yang Z-P, Kuo C-C, Grayston JT (1995) Systemic dissemination of Chlamydia pneumoniae following intranasal inoculation in mice. J Infect Dis 171: 736–738
Moazed TC, Kuo C-C, Grayston JT, Campbell LA (1998) Systemic dissemination of C. pneumoniae infection via macrophages. J Infect Dis 177: 1322–1325
Jackson LA, Campbell LA, Schmidt RA, Kuo C-C, Cappuccio AL, Grayston JT (1997) Specificity of detection of Chlamydia pneumoniae in cardiovascular and non-cardiovascular tissues: evaluation of the innocent bystander hypothesis. Am J Pathol 150: 1785–1790
Boman J, Söderberg S, Forsberg J, Birgander LS, Allard A, Persson K, Jidell E, Kumlin U, Juto P, Waldenström A, Wadell G (1998) High prevalence of Chlamydia pneumoniae DNA in peripheral blood mononuclear cells in patients with cardiovascular disease in middle-aged blood donors. J Infect Dis 178: 274–277
Moazed TC, Campbell LA, Rosenfeld ME, Grayston JT, Kuo C-C (1998) Chlamydia pneumoniae infection accelerates the progression of atherosclerosis in apoE-deficient mice. In: Stephens RS, Byrne GI, Christiansen G, Clark I, Grayston JT, Hatch T, Ridgeway G, Saikku P, Schachter J, Stamm WE (eds) Chlamydial infections. University of California Printing Services, Berkeley, pp 426–429
Piedrahita JA, Zhang SH, Hagaman JR, Oliver PM, Maeda N (1992) Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci USA 189: 4471–4475
Reddick RL, Zhang SH, Maeda N (1994) Atherosclerosis in mice lacking Apo E. Evaluation of lesional development and progression. Atheroscler Thromb 14: 141–147
Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R (1994) ApoE-deficient mice develop lesions of all phases of atherosclerosis. Atheroscler Thromb 14: 133–140
Grönhagen-Riska C, Saikku P, Riska H, Froseth B, Grayston JT (1988) Antibodies to TWAR-a novel type of Chlamydia — in sarcoidosis. In: Grassi C, Rizzato G, Pozzi E (eds) Sarcoidosis and other granulomatous disorders. Excerpta Medica, Amsterdam, pp 297–301
Danesh J, Collins R, Peto R (1997) Chronic infections and coronary heart disease: is there a link? Lancet 350: 430–436
Fong IW, Chiu B, Viira E, Fong MW, Jang D, Mahony J (1997) Rabbit model for Chlamydia pneumoniae infection. J Clin Microbiol 35: 48–52
Laitinen K, Laurila A, Pyhala L, Leinonen M, Saikku P (1997) Chlamydia pneumoniaeinfection induces inflammatory changes in the aortas of rabbits. Infect Immun 65: 4832–4835
Muhlestein JB, Anderson JL, Hammond EH, Zhao L, Trehan S, Schwobe EP, Carlquist JF (1998) Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit model. Circulation 97: 633–636
Laitinen K, Laurila AL, Leinonen M, Saikku P (1996) Reactivation of Chlamydia pneumoniae infection in mice by cortisone treatment. Infect Immun 64: 1488–1490
Malinverni R, Kuo C-C, Campbell LA, Lee A, Grayston JT (1995) Chlamydia pneumoniae (TWAR) pneumonitis: effect of two antibiotic regimens on the course and persistence of infection. Antimicrob Agents Chemother 39: 45–49
Masson MD, Toseland CDN, Beale AS (1995) Relevance of Chlamydia pneumoniaemurine pneumonitis model to evaluation of antimicrobial agents. Antimicrob Agents Chemother 39: 1959–1964
Campbell LA, Moazed TC, Kuo C-C, Grayston JT (1997) Preclinical models for Chlamydia pneumoniae and cardiovascular disease-hypercholesterolemic mice. Presented at Hoechst Marion Roussel. Roundtable on new concepts in the role of intracellular pathogens in chronic diseases. Sydney, Australia, July 2, 1997
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© 1999 Springer-Verlag Italia, Milano
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Campbell, L.A., Kuo, CC. (1999). Chlamydia pneumoniae and Atherosclerosis: Animal Models. In: Allegra, L., Blasi, F. (eds) Chlamydia pneumoniae. Springer, Milano. https://doi.org/10.1007/978-88-470-2280-5_18
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DOI: https://doi.org/10.1007/978-88-470-2280-5_18
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0047-6
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