Chlamydia pneumoniae and Atherosclerosis: Animal Models
The cumulative seroepidemiologic studies, direct detection of Chlamydia pneumoniae antigen in atherosclerotic lesions throughout the arterial tree, and culturing of the organism from atheromatous tissue provide compelling evidence for an association of C. pneumoniae with atherosclerosis . However, these findings do not establish causality, which can only be proven through the use of animal models or intervention studies. This chapter will focus on animal models of C. pneumoniae and their use in studying pathogenesis, intervention strategies for eradication of acute and chronic infection, and putative roles of C. pneumoniae infection on atherogenesis. The recent establishment of mouse and rabbit models of C. pneumoniae infection that also are well-defined experimental models of atherosclerosis has provided the opportunity to address the hypothesis that C. pneumoniae infection affects the onset, severity, or progression of atherosclerosis.
KeywordsAtherosclerotic Lesion Nonhuman Primate Rabbit Model Post Inoculation Single Inoculation
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