Options for Induction and Maintenance of Hypnosis in Anaesthesia

  • A. A. d’Hollander
  • L. Barvais
  • P. Pandin
Conference paper


Total intravenous anaesthesia (TIVA) consists in the administration of at least a hypnotic and quite often a regimen of other drugs that reinforce either analgesia and/or the control of the muscular tone. Among the drugs currently used for TIVA, one must first underline that some degree of hypnosis could be produced by many opioid analgesics [1] and second, that nociceptive reflexes are depressed by hypnotics even at sub-hypnotic doses (concentrations). Loss of consciousness may be induced by different molecular structures acting on the central nervous system. Hypnosis is produced either by more selectively altering a reduced number of neurone clusters or by more diffusely interacting with a very large number of neurones regardless of the localisations of these cells [2]. As a consequence, some additive or potentiation effects are to be considered once drugs with combined pharmacological profiles are administered [3, 4].


Pharmacokinetic Model Parent Drug Infusion Device Hypnotic Drug Total Intravenous Anaesthesia 
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Copyright information

© Springer-Verlag Italia, Milano 1998

Authors and Affiliations

  • A. A. d’Hollander
  • L. Barvais
  • P. Pandin

There are no affiliations available

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