Options for Induction and Maintenance of Hypnosis in Anaesthesia
Total intravenous anaesthesia (TIVA) consists in the administration of at least a hypnotic and quite often a regimen of other drugs that reinforce either analgesia and/or the control of the muscular tone. Among the drugs currently used for TIVA, one must first underline that some degree of hypnosis could be produced by many opioid analgesics  and second, that nociceptive reflexes are depressed by hypnotics even at sub-hypnotic doses (concentrations). Loss of consciousness may be induced by different molecular structures acting on the central nervous system. Hypnosis is produced either by more selectively altering a reduced number of neurone clusters or by more diffusely interacting with a very large number of neurones regardless of the localisations of these cells . As a consequence, some additive or potentiation effects are to be considered once drugs with combined pharmacological profiles are administered [3, 4].
KeywordsPharmacokinetic Model Parent Drug Infusion Device Hypnotic Drug Total Intravenous Anaesthesia
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