Abstract
Hemodynamic changes that occur during hemorrhagic shock (peripheral vasoconstriction, decreased cardiac output, and a falling hemoglobin concentration) diminish the availability of oxygen to the tissues [1, 2]. The resulting tissue hypoxia is a major proximal trigger of the pathophysiological cascade of events which leads to the development of multiple organ system failure after severe hemorrhage and a key determinant of the outcome of hemorrhagic shock [1,3].
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References
Nunn JF, Freeman J (1964) Problems of oxygenation and oxygen transport during hemorrhage. Anaesthesia 19: 206–216
Weil MH, Rakov EC (1986) Cardiovascular system failure. In: Schwartz GR, Safar P, Stone JH, Storey PB, and Wagner DK (eds) Principles and Practice of Emergency Medicine. Saunders, Philadelphia, pp 92–103
Lefer AM (1983) Lysosomes in the pathogenesis of circulatory shock. In: Altura BM, Lefer AM, and Schumer W (eds) Handbook of Shock and Trauma. Raven, New York, pp 291–308
Attar S, Esmond WG, Cowley RA (1962) Hyperbaric oxygenation in vascular collapse. J Thorac Cardiovasc Surg 4: 759–768
Attar S, Scanlan E, Cowley RA (1966) Further evaluation of hyperbaric oxygen in hemorrhagic shock. In: Brown Jr IW, Cox BG (eds) Proceedings of the Third International Conference on Hyperbaric Medicine. Natl Acad Sci, Washington DC, pp 417–429
Cowley RA, Attar S, Blair E, et al (1965) Hyperbaric oxygenation in hypoxic shock. In: Ledingham IM (ed) Hyperbaric Oxygenation: Proceedings of the Second International Congress. Livingstone, Edinburgh, pp 333–341
Elliot DP, Paton BC (1965) Effect 100% oxygen at 1 and 3 atmospheres on dogs subjected to hemorrhagic hypotension. Surgery St Luis 57: 401–408
Hart GB (1974) Exceptional blood loss anemia. Treatment with hyperbaric oxygen. J Am Med Assoc 228: 1028–1029
Crippen D, Safar P, Porter L et al (1991) Improved survival of hemorrhagic shock with oxygen and hypothermia in rats. Resuscitation 21: 271–281
Atkins J, Johnson K, Scott Z et al (1995) Oxygen inhalation increases mean arterial blood pressure (MABP) in hemorrhaged rats. Shock 3: 30
Frank HA, Fine J (1942) Traumatic shock. V. A. study of the effect of oxygen on hemorrhagic shock. J Clin Invest 22: 305–314
Jacobson YG, Defalco AJ, Mundth ED et al (1965) Hypebaric oxygen in the therapy of experimental hemorrhagic shock. Surg Forum 16: 15–17
Adir Y, Katz E, Bitterman N et al (1995) Salutary consequences of oxygen therapy on the long-term outcome of hemorrhagic shock in awake unrestrained rats. Undersea & Hyperbaric Med 22: 23–30
Bitterman H, Reissman P, Bitterman N et al (1991) Oxygen therapy in experimental hemorrhagic shock. Circ Shock 33: 183–191
Bitterman H, Bitterman N, Melamed Y et al (1989) Effects of hyperbaric oxygen (HBO) in circulatory shock induced by splanchnic artery occlusion and reperfusion in rats. Can J Physiol Pharmacol 67: 1033–1037
Lambertsen CJ (1965) Effects of oxygen at high partial pressure. In: Handbook of Physiology. Respiration. Am Physiol Soc, Washington DC, sect 3, vol II, chapt 39, pp 1027–1046
Hahnloser PB, Domanig E, Lanphier E et al (1966) Hyperbaric oxygenation: alterations in cardiac output and regional blood flow. J Thorac Cardiovasc Surg 52: 223–231
Hordnes C, Tyssebotn I, Onarheim J (1982) Effect of high ambient pressure and oxygen tension on organ blood flow in conscious rats. Acta Physiol Scand 114: 23A
Onarheim J, Tyssebotn I (1980) Effect of high ambient pressure and oxygen tension on organ blood flow in the anesthetized rat. Undersea Biomed Res 7: 47–60
Bitterman H, Brod V, Weisz G et al (1996) Effects of oxygen on regional hemodynamics in hemorrhagic shock. Am J Physiol 271: H203–H211
Bitterman N, Bitterman H, Kinarty A et al (1993) Effect of a single exposure to hyperbaric oxygen on blood mononuclear cells in human subjects. Undersea & Hyperbaric Med 20: 197–204
Bitterman N, Lahat N, Rosenwald T et al (1994) The effect of hyperbaric oxygen on tissue distribution of mononuclear cell subsets in the rat. J App Physiol 77: 2355–2359
Lahat N, Bitterman H, Yaniv N et al (1995) Exposure to hyperbaric oxygen induces tumor necrosis factor secretion form rat macrophages. Clin Exp Immunol 102: 655–659
Zamboni WA, Roth AC, Russell RD et al (1993) Morphological analysis of the microcirculation during reperfusion of ischemic skeletal muscle and the effect of hyperbaric oxygen. Plast Reconstr Surg 91: 1110–1123
Sirsjo A, Lehr HA, Nolte D et al (1993) Hyperbaric oxygen treatment enhances the recovery of blood flow and functional capillary density in postischemic striated muscle. Circ Shock 40: 9–13
Clark JM (1982) Oxygen toxicity. In: Bennet PB, Elliot DH (eds) The Physiology and Medicine of Diving. Bailliere Tindall, London, pp 200–238
Klein J (1990) Normobaric oxygen toxicity. Anesth Analg 70: 195–207
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Bitterman, H., Brod, V., Bitterman, N. (1998). Hemodynamic Effects of Hyperoxia in Hemorrhagic Shock. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine - A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2278-2_48
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DOI: https://doi.org/10.1007/978-88-470-2278-2_48
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