Use of Propacetamol in Postoperative Pain

  • H. Adriaensen
  • V. Saldien
Conference paper


Propacetamol is a prodrug of paracetamol. It is a di-ethylglycidyl-esther of paracetamol which is watersoluble. For its intravenous use, propacetamol is diluted as a solution of 2 g propacetamol in 125 ml glucose 5% and administered over a period of 10 to 15 minutes.


Total Knee Arthroplasty Postoperative Pain Analgesic Effect Analgesic Efficacy Hallux Valgus 
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  1. 1.
    Depré M, Van Hecken A, Verbesselt R et al (1992) Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use. Fundam Clin Pharmacol 6: 259–262PubMedCrossRefGoogle Scholar
  2. 2.
    Granry JC, Rod B, Boccard E et al (1992) Pharmacokinetics and antipyretic effects of an injectable prodrug of paracetamol (propacetamol) in children. Peadiatric Anaesthesia 2: 219–295Google Scholar
  3. 3.
    Autret E, Dutertre JP, Breteau M et al (1993) Pharmacokinetics of paracetamol in the neonate and infant after administration of propacetamol chlorhydrate. Dex Pharmacol Ther 10: 129–134Google Scholar
  4. 4.
    Marichy J, Bouchard C, Nombret T et al (1989) Efficacité antipyrétique du propacétamol chez des enfants brûlés graves. Cahiers d’Anesthésiologie 37;7: 521–523PubMedGoogle Scholar
  5. 5.
    Patel A (1995) Internal Study Report, UPSA Medica, Agen, FranceGoogle Scholar
  6. 6.
    Jarde O, Boccard E (1997) Difference of paracetamol analgesic activity between oral and parenteral routes. Clinical Drug Investigation (in press)Google Scholar
  7. 7.
    Hynes D, Mc Caroll M, Gerin M et al (1996) Propacetamol vs Diclofenac and placebo for postoperative pain control after total hip arthroplasty. World Congress on Pain, Vancouver Canada, Abstract 266: 161Google Scholar
  8. 8.
    Ang ET, Goldfarb G, Boccard E (1990) Analgesic efficacy of propacetamol hydrochloride 2 g versus pentazocine 30 mg after orthopedic surgery. Eur J Pain 11: 137–142Google Scholar
  9. 9.
    Lepoittevin L, Monrigal C, Rod B et al (1991) Conference on the “Management of Acute and Cancer Pain”. 27–28 April, ParisGoogle Scholar
  10. 10.
    Thys J, Veekman L, Gerin MG et al (1993) Relative analgesic efficacy of propacetamol, a prodrug of paracetamol for i.v. use, and morphine in postoperative pain. 7th World Congress on Pain, Paris, FranceGoogle Scholar
  11. 11.
    Farcas JC, Larrouturou P, Morin JP et al (1992) Analgesic efficacy of an injectable acetominophen versus a dipyrone plus pitofenone plus fenpiverinium association after abdominal aortic repair. Curr Ther Res 51: 19–27Google Scholar
  12. 12.
    Delbos A, Boccard E (1995) The morphine-sparing effect of propacetamol in orthopedic postoperative pain. Journal of Pain and Symptom Management 10; 4: 279–286PubMedCrossRefGoogle Scholar
  13. 13.
    Rit O, Bertram L, Joris J et al (1997) Effects of systemic administration of propacetamol on pain after total knee arthroplasty. Residents Meeting of the Belgian Association of Anesthesia and Reanimation. Liège, BelgiumGoogle Scholar
  14. 14.
    Granry JC (1997) Study of the efficacy and safety of propacetamol in children with post-operative orthopaedic surgery pain. Br J Anaesth (in press)Google Scholar
  15. 15.
    Luthy CS, Collart L, Striberni R et al (1992) The rate of administration influences the analgesic effect of paracetamol (abstract) 5th World Conference on clinical pharmacology and therapeutics, Yokohama, JapanGoogle Scholar

Copyright information

© Springer-Verlag Italia, Milano 1998

Authors and Affiliations

  • H. Adriaensen
  • V. Saldien

There are no affiliations available

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