Abstract
In recent years the role of the liver in acid-base homeostasis has undergone a dramatic shift. Previous studies had promoted the kidney as central to hydrogen and bicarbonate clearance but it is now clear that control of acid-base homeostasis is a multi-organ function involving close co-ordination between liver, kidney, muscle and lungs.
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References
Oliver J, Bourke E (1975) Adaptations in urea and ammonium excretion in metabolic acidosis in the rat. Clin Sci Mol Med 48: 515–520
Haussinger D, Gerok W (1985) Hepatic urea synthesis and pH regulation; role of CO2, HCO3-, pH and activity of carbonic anhydrase. Eur J Biochem 152: 381–386
Haussinger D, Steele R, Gerok W (1992) Metabolic alkalosis as driving force for urea synthesis in liver disease. Pathogenetic model and therapeutic implications. Clin Invest 70: 411–415
Cohen R (1991) Roles of the liver and kidney in acid-base regulation and its disorders. Brit J Anaesth 67: 154–164
Metcalfe H, Monson J, Welch S, Cohen R (1986) Inhibition of lactate removal by ketone bodies in rat liver, evidence for a quantitatively important role of the plasma membrane lactate transporter in lactate metabolism. J Clin Invest 78: 743–747
Record C, Iles R, Cohen R, Williams R (1975) Acid base and metabolic disturbances in fulminant hepatic failure. Gut 16: 144–149
Haussinger D, Steele R, Gerok W (1990) Ammonium and bicarbonate homeostasis in chronic liver disease. Klinische Wochenschrift 68: 175–182
Ui M (1966) A role of phosphofructokinase on pH-dependent regulation of glycolysis. Biochem Biophys Acta 124: 310–322
Record C, Chase R, Williams R, Appleton D (1981) Disturbances in lactate metabolism in patients with liver damage due to paracetamol overdose. Metabolism 30: 638–643
Woll P, Record C (1979) Lactate elimination in man; effects of lactate concentration and hepatic dysfunction. Eur J Clin Invest 9: 397–404
Bihari D, Gimson AE, Lindridge J et al (1985) Lactic acidosis in fulminant hepatic failure. Some aspects of pathogenesis and prognosis. J. Hepatol 1(4): 405–416
Bihari D, Gimson AE, Waterson M, Williams R (1985) Tissue hypoxia during fulminant hepatic failure. Crit Care Med 13(12): 1034–1039
Harrison PM, Wendon JA, Gimson AE et al (1991) Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med 324(26): 1852–1857
Wendon JA, Harrison PM, Keays R et al (1992) Effects of vasopressor agents and epoprostenol on systemic hemodynamics and oxygen transport in fulminant hepatic failure. Hepatology 15(6): 1067–1071
O’Grady JG, Gimson AE, O’Brien CJ et al (1988) Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure. Gastroenterology 94(5 Pt 1): 1186–1192
O’Grady JG, Alexander GJM, Hallyar KM, Williams R (1989) Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 97: 439–445
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© 1998 Springer-Verlag Italia, Milano
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Gimson, A.E.S. (1998). Acid-Base Disturbances during Fulminant Hepatic Failure. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine - A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2278-2_40
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DOI: https://doi.org/10.1007/978-88-470-2278-2_40
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0007-0
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