Metabolism after Injury: The Effects of G.H.

  • G. Biolo
  • F. Iscra
  • G. Toigo
  • A. Gullo
  • G. Guarnieri
Conference paper


The metabolic response to severe trauma involves an increased loss of body proteins [1]. Specific sites of changes of protein and amino acid metabolism have been identified. In skeletal muscle, the rate of protein degradation is greatly accelerated. Depressed protein synthesis may also contribute to the catabolic response. However, despite the fact that both total muscle RNA and specific myofibrillar protein mRNA [2] levels were drastically reduced in trauma, studies utilizing stable isotopes have often reported increased rates of whole-body and muscle protein synthesis in patients [1, 3]. It may be hypothesized that increased availability of intracellular amino acids derived from proteolysis may directly stimulate protein synthesis, possibly with a post-transcriptional mechanism.


Growth Hormone Branch Chain Amino Acid Muscle Protein Synthesis Stimulate Protein Synthesis Free Amino Acid Concentration 
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Copyright information

© Springer-Verlag Italia, Milano 1998

Authors and Affiliations

  • G. Biolo
  • F. Iscra
  • G. Toigo
  • A. Gullo
  • G. Guarnieri

There are no affiliations available

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