Iatrogenic Lung Damage by Artificial Ventilation Clinical Confirmation

  • C. S. V. Barbas
Conference paper


There is a growing body of experimental evidence suggesting that cyclic mechanical distention of the diseased lung during mechanical ventilation (MV) may be detrimental. The use of high tidal volumes in healthy animals - generated either by high positive alveolar pressures or by very negative pleural pressures - has been associated with a lung injury process that is indistinguishable from severe Acute Respiratory Distress Syndrome (ARDS). More devastating than the toxic effects of high inspired oxygen fractions, this process seems to be exacerbated by previous lung injury, high respiratory rates, and end-expiratory alveolar collapse with cyclic reopening during inspiration.


Respir Crit Pressure Support Ventilation High Tidal Volume Permissive Hypercapnia Lower Inflection Point 
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Copyright information

© Springer-Verlag Italia, Milano 1998

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  • C. S. V. Barbas

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