Advertisement

The Syndrome of Nocturnal Frontal Lobe Epilepsy

  • P. Tinuper
  • G. Plazzi
  • F. Provini
  • A. Cerullo
  • E. Lugaresi

Abstract

Partial epileptic seizures may arise in any point of the cerebral cortex. The clinical aspect of one seizure depends on the site of onset and the cortical area involved by the ictal discharge. Most of our knowledge of the semiological features of frontal partial seizures comes from stereotactic electroencephalogram (EEG) recordings of the seizures in patients undergoing functional neurosurgery for medically refractory partial epileptic seizures [1–9]. These studies describe attacks characterized by vocalization, screaming and complex motor behavior with bimanual and bipedal activity. Seizures are often nocturnal and tend to recur in clusters. Scalp EEG may be misleading in localizing the epileptic foci, in particular in seizures originating from the frontal lobes, due to the presence of large mesial and orbital surfaces [10].

Keywords

Frontal Lobe Frontal Lobe Epilepsy Nocturnal Frontal Lobe Epilepsy Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Paroxysmal Dystonia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Tharp BR (1972) A unique electroencephalographic and clinical syndrome. Epilepsia 13:627–642PubMedCrossRefGoogle Scholar
  2. 2.
    Geier S, Bancaud J, Talairach J, Bonis A, Szikla G, Enjelvin M (1977) The seizures of frontal lobe epilepsy. Neurology 27:951–958PubMedGoogle Scholar
  3. 3.
    Wada JA, Purves SJ (1984) Oral and bimanual-bipedal activity as ictal manifestations of frontal lobe epilepsy. Epilepsia 25:668CrossRefGoogle Scholar
  4. 4.
    Williamson PD, Spencer DD, Spencer SS, Novelly RA, Mattson RH (1985) Complex partial seizures of frontal lobe origin. Ann Neurol 18:497–504PubMedCrossRefGoogle Scholar
  5. 5.
    Delgado-Esqueta AV, Swartz BE, Maldonado HM, Walsh GO, Rand RW, Halgren E (1987) Complex partial seizures of frontal lobe origin. In: Wieser HG, Engel J Jr (eds) Presurgical evaluation of epileptics. Springer-Verlag, Berlin, pp 267–299CrossRefGoogle Scholar
  6. 6.
    Waterman K, Purves SJ, Kosaka B, Strauss E, Wada JA (1987) An epileptic syndrome caused by mesial frontal lobe seizure foci. Neurology 37:577–582PubMedGoogle Scholar
  7. 7.
    Morris HH, Dinner DS, Luders H, Wyllie E, Kramer R (1988) Supplementary motor seizures: clinical and electroencephalographic findings. Neurology 36:1075–1082Google Scholar
  8. 8.
    Wada JA (1988) Nocturnal recurrence of brief, intensely affective vocal and facial expression with powerful bimanual, bipedal, axial, and pelvic activity with rapid recovery as manifestations of mesial frontal lobe seizures. Epilepsia 29:209Google Scholar
  9. 9.
    Bancaud J, Talairach J (1992) Clinical semiology of frontal lobe seizures. In: Chauvel P, Delgado-Esqueta AV, Halgren E, Bancaud J (eds) Frontal lobe seizures and epilepsies. Advances in Neurology, vol. 57. Raven, New York, pp 3–58Google Scholar
  10. 10.
    Ajmone Marsan C (1988) Seizures originating from the orbital cortex of the frontal lobe. Epilepsia 29:208Google Scholar
  11. 11.
    Lugaresi E, Cirignotta F (1981) Hypnogenic paroxysmal dystonia: epileptic seizures or a new syndrome? Sleep 4:129–138PubMedGoogle Scholar
  12. 12.
    Lugaresi E, Cirignotta F, Montagna P (1986) Nocturnal paroxismal dystonia. J Neurol Neurosurg Psychiatry 49:375–380PubMedCrossRefGoogle Scholar
  13. 13.
    Rajna P, Kundra O, Halasz P (1983) Vigilance level-dependent tonic sezures. Epilepsy or sleep disorder? A case report. Epilepsia 24:725–733PubMedCrossRefGoogle Scholar
  14. 14.
    Crowell JA, Anders TF (1985) Hypnogenic paroxysmal dystonia. Acad Chil Psychiatry 24:353–358CrossRefGoogle Scholar
  15. 15.
    Godbout R, Montplaisir J, Roleau I (1985) Hypnogenic paroxysmal dystonia: epilepsy or sleep disorder? A case report. Clin Electroencephalgr 16:136–142Google Scholar
  16. 16.
    Lee BI, Lesser RP, Pippenger CE, Morris HH, Luders H, Dinner DS, Corrie WS, Murphy WF(1985) Familial paroxysmal hypnogenic dystonia. Neurology 35:1357–1360PubMedGoogle Scholar
  17. 17.
    Berger HJC, Berendsen-Versteeg TMC, Joosten EMG (1987) Nocturnal paroxysmal dystonia. J Neurol Neurosurg Psychiatry 50:647–648PubMedCrossRefGoogle Scholar
  18. 18.
    Kovacevic-Ristanovic R, Golbin A, Cartwright R (1988) Nocturnal conversion disorder and nocturnal paroxysmal dystonia. Similiarities and treatments. Sleep Res 17:204.Google Scholar
  19. 19.
    Tinuper P, Cerullo A, Cirignotta F, Cortelli P, Lugaresi E, Montagna P (1990) Nocturnal paroxysmal dystonia with short-lasting attacks: three cases with evidence for an epileptic frontal lobe origin of seizures. Epilepsia 31:549–556PubMedCrossRefGoogle Scholar
  20. 20.
    Sforza E, Montagna P, Rinaldi R, Tinuper P, Cerullo A, Cirignotta F, Lugaresi E (1993) Paroxysmal periodic motor attacks during sleep: clinical and polygraphic features. Electroencephalogr Clin Neurophysiol 86:161–166PubMedCrossRefGoogle Scholar
  21. 21.
    Montagna P, Sforza E, Tinuper P, Cirignotta F, Lugaresi E (1990) Paroxysmal arousals during sleep. Neurology 40:1063–1066PubMedGoogle Scholar
  22. 22.
    Plazzi G, Tinuper P, Montagna P, Provini F, Lugaresi E (1995) Epileptic nocturnal wanderings. Sleep 18:749–756PubMedGoogle Scholar
  23. 23.
    Gastaut H, Broughton RJ (1965) A clinical and polygraphic study of episodic phenomena during sleep. In: Wortis J (ed) Recent advances in biology and psychiatry, vol. 7. Plenum, New York, pp 197–222Google Scholar
  24. 24.
    Broughton RJ (1968) Sleep disorders: disorders of arousal? Science 159:1070–1078PubMedCrossRefGoogle Scholar
  25. 25.
    Tassinari CA, Mancia D, Dalla Bernardina B, Gastaut H (1972) Pavor nocturnus of non-epileptic nature in epileptic children. Electroencephalogr Clin Neurophysiol 33:603–607PubMedCrossRefGoogle Scholar
  26. 26.
    Pedley TA, Guilleminault C (1977) Episodic nocturnal wandering responsive to anticonvulsant drug therapy. Ann Neurol 2:30–35PubMedCrossRefGoogle Scholar
  27. 27.
    Maselli RA, Rosemberg RS, Spire JP (1988) Episodic nocturnal wandering in non-epileptic young patients. Sleep 11:156–161PubMedGoogle Scholar
  28. 28.
    Oswald J (1989) Episodic nocturnal wandering. Sleep 12:186–187PubMedGoogle Scholar
  29. 29.
    Montagna P (1992) Nocturnal paroxysmal dystonia and nocturnal wandering. Neurology 42(supp 6):61–67PubMedGoogle Scholar
  30. 30.
    Lugaresi E, Coccagna G, Mantovani M, Lebrun R (1972) Some periodic phenomena arising during drowsiness and sleep in man. Electroencephalogr Clin Neurophysiol 32:701–705PubMedCrossRefGoogle Scholar
  31. 31.
    Scheffer IE, Bhathia KP, Lopes-Cendes I, Fish DR, Marsden CD, Andermann F (1994) Autosomal dominant frontal epilepsy misdiagnosed as sleep disorder. Lancet 343:515–517PubMedCrossRefGoogle Scholar
  32. 32.
    Sheffer IE, Bhathia KP, Lopes-Cendes I, Fish DR, Marsden CD, Andermann E, Andermann F, Desbiens R, Keene D, Cendes F, Manson JI, Constantinou JEC, Mcintosh A, Berkovic SF (1995) Autosomal dominant nocturnal frontal lobe epilepsy: a distinctive clinical disorder. Brain 118:61–73CrossRefGoogle Scholar
  33. 33.
    Oldani A, Zucconi M, Ferini-Strambi L, Bizozzero D, Smirne S (1996) Autosomal dominant nocturnal frontal lobe epilepsy: electroclinical picture. Epilepsia 37:964–976PubMedCrossRefGoogle Scholar
  34. 34.
    Phillips HA, Sheffer IE, Berkovic SF, Hollway GE, Sutherland GR, Mulley JC (1995) Localisation of gene for autosomal dominant nocturnal frontal lobe epilepsy to chromosome 20ql3.2. Nat Genet 10:117–118PubMedCrossRefGoogle Scholar
  35. 35.
    Berkovic SF, Phillips HA, Sheffer IE, Lopes-Cendes I, Bhatia KP, Fish DR, Marsden CD, Andermann E, Andermann F, Sutherland GR, Mulley JC (1995) Genetic heterogeneity in autosomal dominant nocturnal frontal lobe epilepsy. Epilepsia 36(suppl 4):147Google Scholar
  36. 36.
    Tinuper P, Montagna P, Cerullo A, Plazzi G, Provini F, Mochi M, Lugaresi E (1996) Autosomal dominant nocturnal epilepsy: a family with brain migration disorder and chromosome 18 duplication. Epilepsia 37(suppl 5):37CrossRefGoogle Scholar
  37. 37.
    Mochi M, Provini F, Plazzi G, Corsini R, Tinuper P, Valentino ML, Lugaresi E, Montagna P (1997) Genetic heterogeneity in autosomal dominant nocturnal frontal lobe epilepsy. It J Neurol Sci (in press)Google Scholar

Copyright information

© Springer-Verlag Italia, Milano 1997

Authors and Affiliations

  • P. Tinuper
    • 1
  • G. Plazzi
    • 1
  • F. Provini
    • 1
  • A. Cerullo
    • 1
  • E. Lugaresi
    • 1
  1. 1.Istituto di NeurologiaUniversità di BolognaBolognaItaly

Personalised recommendations