Circadian Rhythm of Body Core Temperature in Neurodegenerative Diseases

  • G. Pierangeli
  • P. Cortelli
  • F. Provini
  • G. Plazzi
  • E. Lugaresi


Diurnal variations in body temperature have been evident since the eighteenth century [1, 2]. A century later Gierse [3] and Ogle [4] documented 24-hour oscillations of body temperature in man. Simpson and Galbraith [5] were the first to measure the circadian rhythm of core body temperature (CRT) of animals placed under conditions of constant illumination or darkness, and to observe that the rhythm persisted unaltered suggesting the endogenous nature of the oscillations. The endogenous nature of circadian rhythms (CR) was confirmed by studying the golden hamster with a genetic mutation that produced a very short circadian rhythm of activity (a period of 20 instead of 24 h) [6].


Circadian Rhythm Multiple System Atrophy Body Core Temperature Autonomic Failure NREM Sleep 
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Copyright information

© Springer-Verlag Italia, Milano 1997

Authors and Affiliations

  • G. Pierangeli
    • 1
  • P. Cortelli
    • 1
  • F. Provini
    • 1
  • G. Plazzi
    • 1
  • E. Lugaresi
    • 1
  1. 1.Istituto di NeurologiaUniversità di BolognaBolognaItaly

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