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Biochemical Approach to the Wake-Sleep Cycle

  • G. Zamboni
  • E. Perez
  • R. Amici

Abstract

The biochemistry of waking and sleeping processes seems to engulf the whole of the brain’s functions; the molecular description of the mechanisms involved constitutes one of the most fundamental explanatory levels available. In the case of the wake-sleep cycle, the gap in knowledge existing between molecules and these behavioural states has been filled on the assumption that wake-sleep processes are the expression of some general function concerning both the brain and the body, and thus, both widespread neuronal and humoral influences have been investigated. Both pathways imply that neuronal or non-neuronal cells release substances which control the behavioural states of waking and sleeping by acting on regulatory centres. However, there are two tasks that should be fulfilled in order to clarify how the control of waking and sleeping is organized at the molecular level: the first is to identify the substance(s) involved and the other is to assess the location(s) of their effects, that is, the components of the nervous circuit involved in the control.

Keywords

Sleep Deprivation cAMP Concentration NREM Sleep Biochemical Approach American Physiological Society 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Borbély AA, Tobler I (1989) Endogenous sleep-promoting substances and sleep regulation. Physiol Rev 69:605–670PubMedGoogle Scholar
  2. 2.
    Jones BE (1994) Basic mechanisms of sleep-wake states. In: Kryger MH, Roth T, Dement WE (eds) Principles and practice of sleep medicine. WB Saunders, London, pp 145–162Google Scholar
  3. 3.
    Kapás L, Obál FJr, Krueger JM (1993) Humoral regulation of sleep. Int Rev Neurobiol 35:131–160PubMedCrossRefGoogle Scholar
  4. 4.
    Parmeggiani PL (1982) Regulation of physiological functions during sleep in mammals. Experientia 38:1405–1408PubMedCrossRefGoogle Scholar
  5. 5.
    Parmeggiani PL (1994) The autonomic nervous system in sleep. In: Kryger MH, Roth T, Dement WE (eds) Principles and practice of sleep medicine. WB Saunders, London, pp 194–203Google Scholar
  6. 6.
    Parmeggiani PL, Morrison AR (1990) Alterations in autonomic functions during sleep. In: Loewy AD, Spyer KM (eds) Central regulation of autonomic functions. Oxford University Press, Oxford, pp 367–386Google Scholar
  7. 7.
    Moruzzi G (1972) The sleep-waking cycle. Rev Physiol 64:1–165Google Scholar
  8. 8.
    Loewy AD (1990) Anatomy of the autonomic nervous system: An overview. In: Loewy AD, Spyer KM (eds) Central regulation of autonomic functions. Oxford University Press, Oxford, pp 3–16Google Scholar
  9. 9.
    Loewy AD (1991) Forebrain nuclei involved in autonomic control. In: Holstege G (ed) Role of the forebrain in sensation and behavior. Prog Brain Res 87:253–268CrossRefGoogle Scholar
  10. 10.
    Guyenet PC (1991) Central noradrenergic neurons: the autonomic connection. In: Barnes CD, Pompeiano O (eds) Neurobiology of the locus coeruleus. Prog Brain Res 88:365–380CrossRefGoogle Scholar
  11. 11.
    Nieuwenhuys R (1985) Chemoarchitecture of the brain. Springer-Verlag, Berlin Heidelberg, pp 177–193CrossRefGoogle Scholar
  12. 12.
    Nieuwenhuys R, Veening JG, Domburg PV (1988/89) Core and paracores: some new chemoarchitectural entities in the mammalian neuraxis. Acta Morphol Neerl Scand 26:131–163PubMedGoogle Scholar
  13. 13.
    Swanson LW (1986) Organization of mammalian neuroendocrine system. In: Mountcastle VB, Bloom FE, Geiger SR (eds) Intrinsic regulatory systems of the brain.(Handbook of physiology, sect 1, The nervous system, vol IV) American Physiological Society, Bethesda, pp 317–363Google Scholar
  14. 14.
    Swanson LW (1987) The hypothalamus. In: Björklund A, Hökfelt T, Swanson LW (eds) Integrated systems of the CNS. (Handbook of chemical neuroanatomy, part 1, vol 5) Elsevier, Amsterdam, pp 1–124Google Scholar
  15. 15.
    Butcher LL, Woolf NJ (1984) Histochemical distribution of acetylcholinesterase in the central nervous system: clues to the localization of cholinergic neurons. In: Björklund A, Hökfelt T, Kuhar MJ (eds) Classical transmitters and transmitter receptors in the CNS. (Handbook of chemical neuroanatomy, part II, vol 3). Elsevier, Amsterdam, pp 1–50Google Scholar
  16. 16.
    Björklund A, Lindvall O (1986) Catecholaminergic brain stem regulatory systems. In: Mountcastle VB, Bloom FE, Geiger SR (eds) Intrinsic regulatory systems of the brain (Handbook of physiology, sect 1, The nervous system, vol IV). American Physiological Society, Bethesda, pp 155–235Google Scholar
  17. 17.
    Striker EM, Zigmond MJ (1986) Brain monoamines, homeostasis and adaptive behavior. In: Mountcastle VB, Bloom FE, Geiger SR (eds) Intrinsic regulatory systems of the brain (Handbook of physiology, sect 1, The nervous system, vol IV). American Physiological Society, Bethesda, pp 677–700Google Scholar
  18. 18.
    Aghajanian GK, Vandermaelen CP (1986) Specific systems of the reticular core: Serotonin. In: Mountcastle VB, Bloom FE, Geiger SR (eds) Intrinsic regulatory systems of the brain (Handbook of physiology, sect 1, The nervous system, vol IV). American Physiological Society, Bethesda, pp 237–256Google Scholar
  19. 19.
    Hobson JA, Steriade M (1986) Neuronal basis of behavioral state control. In: Mountcastle VB, Bloom FE, Geiger SR (eds) Intrinsic regulatory systems of the brain (Handbook of physiology, sect 1, The nervous system, vol IV). American Physiological Society, Bethesda, pp 701–823Google Scholar
  20. 20.
    Giuditta A (1977) The biochemistry of sleep. In: Davison AN (ed) Biochemical correlates of brain structure and function. Academic Press, New York, pp 293–337Google Scholar
  21. 21.
    Karnovsky ML, Reich P (1977) Biochemistry of sleep. In: Agranoff BW, Aprison MH (eds) Advances in neurochemistry, vol 2. Plenum, New York, pp 213–275Google Scholar
  22. 22.
    Giuditta A, Perrone Capano C, Grassi Zucconi G (1984) The neurochemical approach to the study of sleep. In: Lajtha A (ed) Handbook of neurochemistry, vol 8. Plenum, New York, pp 443–476Google Scholar
  23. 23.
    Madsen PL, Vorstrup S (1991) Cerebral blood flow and metabolism during sleep. Cerebrovasc Brain Metab Rev 3:281–296PubMedGoogle Scholar
  24. 24.
    Franzini C (1992) Brain metabolism and blood flow during sleep. J Sleep Res 1:3–16CrossRefGoogle Scholar
  25. 25.
    Sokoloff L (1996) Cerebral metabolism and visualization of cerebral activity. In: Greger R, Windhorst V (eds) Comprehensive human physiology, vol 1. Springer-Verlag, Berlin Heidelberg, pp 579–602Google Scholar
  26. 26.
    Fox PT, Raichle ME, Mintum MA, Deuce C (1988) Nonoxidative glucose consumption during focal physiologic neural activity. Science 241:462–464PubMedCrossRefGoogle Scholar
  27. 27.
    Mata M, Fink DJ, Gainer H, Smith CB, Davidsen L, Savaki H, Schwartz WJ, Sokoloff L (1980) Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity. J Neurochem 34:214–215CrossRefGoogle Scholar
  28. 28.
    Kadekaro M, Crane AM, Sokoloff L (1985) Differential effects of electrical stimulation of sciatic nerve on metabolic activity in spinal cord and dorsal root ganglion in the rat. Proc Natl Acad Sei USA 82:6010–6013CrossRefGoogle Scholar
  29. 29.
    Ramm P, Frost BJ (1983) Regional metabolic activity in the rat brain during sleep-wake activity. Sleep 6:196–216PubMedGoogle Scholar
  30. 30.
    Ramm P, Frost BJ (1986) Cerebral and local cerebral metabolism in the cat during slow wave and rem sleep. Brain Res 365:112–124PubMedCrossRefGoogle Scholar
  31. 31.
    Abrams RM, Hutchinson AA, Jay TM, Sokoloff L, Kennedy C (1988) Local cerebral glucose utilization non-selectively elevated in rapid eye movement sleep of the fetus. Dev Brain Res 40:65–70CrossRefGoogle Scholar
  32. 32.
    Maquet P, Dive D, Salmon E, Sadzot B, Franco G, Poirrier R, von Frenckell R, Franck G (1990) Cerebral glucose utilization during sleep-wake cycle in man determined by positron emission tomography and [18f]2-fluoro-2-deoxy-D-glucose method. Brain Res 513:136–143PubMedCrossRefGoogle Scholar
  33. 33.
    Lydie R, Baghdoyan HA, Hibbard L, Bonyak EV, DeJoseph MR, Hawkins RA (1991) Regional brain glucose metabolism is altered during rapid eye movement sleep in the cat: a preliminary study. J Comp Neurol 304:517–529CrossRefGoogle Scholar
  34. 34.
    Siggins GR, Gruol DL (1986) Mechanisms of transmitter action in the vertebrate central nervous system. In: Mountcastle VB, Bloom FE, Geiger SR (eds) Intrinsic regulatory systems of the brain (Handbook of physiology, sect 1, The nervous system, vol IV). American Physiological Society, Bethesda, pp 1–114Google Scholar
  35. 35.
    Hemmings HC Jr, Nairn AC, McGuinnes TL, Huganir RL, Greengard P (1989) Role of protein phosphorylation in neuronal signal transduction. FASEB J 3:1583–1592PubMedGoogle Scholar
  36. 36.
    Parmeggiani PL (1980) Temperature regulation during sleep: A study in homeostasis. In: Orem J, Barnes CD (eds) Physiology in sleep. Academic Press, London, pp 97–143Google Scholar
  37. 37.
    Parmeggiani PL (1988) Thermoregulation during sleep from the viewpoint of homeostasis. In: Lydic R, Biebuyek JF (eds) Clinical physiology of sleep. American Physiological Society, Bethesda, pp 159–169Google Scholar
  38. 38.
    Parmeggiani PL, Rabini C (1967) Shivering and panting during sleep. Brain Res 6:789–791PubMedCrossRefGoogle Scholar
  39. 39.
    Zepelin H (1994) Mammalian sleep. In: Kryger MH, Roth T, Dement WE (eds) Principles and practice of sleep medicine. WB Saunders, London, pp 69–80Google Scholar
  40. 40.
    Boulant JA (1980) Hypothalamic control of thermoregulation. In: Morgane PJ, Panksepp J (eds) Behavioral studies of the hypothalamus.(Handbook of the hypothalamus, vol 3, part A) Marcel Dekker, New York Basel, pp 1–82Google Scholar
  41. 41.
    Simon E, Pierau F-K, Taylor DCM (1986) Central and peripheral thermal control of effectors in homeothermic temperature regulation. Physiol Rev 66:235–300PubMedCrossRefGoogle Scholar
  42. 42.
    Crosby EC, Showers MJC (1969) Comparative anatomy of the preoptic and hypothalamic areas. In: Haymaker W, Anderson E, Nauta WJH (eds) The hypothalamus. Charles C Thomas, Springfield, Illinois, pp 61–135Google Scholar
  43. 43.
    Prosser CL (ed) (1991) Comparative animal physiology: Neural and intergrative animal physiology. Wyley-Liss, New YorkGoogle Scholar
  44. 44.
    Johnson KG, Hales JRS (1984) An introductory analysis of competition between thermoregulation and other homeostatic systems. In: Hales JRS (ed) Thermal physiology. Raven, New York, pp 295–298Google Scholar
  45. 45.
    Parmeggiani PL, Rabini C (1970) Sleep and environmental temperature. Arch Ital Biol 108:369–387PubMedGoogle Scholar
  46. 46.
    Parmeggiani PL, Rabini C, Cattalani M (1969) Sleep phases at low environmental temperature. Arch Sei Biol 53:277–290Google Scholar
  47. 47.
    Glotzbach SF, Heller HC (1994) Temperature regulation. In: Kryger MH, Roth T, Dement WE (eds) Principles and practice of sleep medicine. WB Saunders, London, pp 260–275Google Scholar
  48. 48.
    Benington JH, Heller HC (1994) REM-sleep timing is controlled homeostatically by accumulation of REM-sleep propensity in non-REM sleep. Am J Physiol 266:R1992-R2000PubMedGoogle Scholar
  49. 49.
    Borbély AA (1994) Sleep homeostasis and models of sleep regulation. In: Kryger MH, Roth T, Dement WE (eds) Principles and practice of sleep medicine. WB Saunders, London, pp 309–320Google Scholar
  50. 50.
    Rosenberg RS, Bergmann BM, Rechtschaffen AA (1976) Variations in slow wave activity during sleep in the rat. Physiol Behav 17:931–938PubMedCrossRefGoogle Scholar
  51. 51.
    Trachsel L, Tobler I, Borbély AA (1988) Electroencephalogram analysis of non-rapid eye movement sleep in rats. Am J Physiol 255:R27–R37PubMedGoogle Scholar
  52. 52.
    Borbély AA, Neuhaus HV (1979) Sleep-deprivation: effects on sleep and EEG in the rat. J Comp Physiol 133:71–87CrossRefGoogle Scholar
  53. 53.
    Friedman L, Bergmann BM, Rechtschaffen AA (1979) Effects of sleep deprivation on sleepiness, sleep intensity, and subsequent sleep in the rat. Sleep 1:369–391PubMedGoogle Scholar
  54. 54.
    Borbély AA, Tobler I, Hanagasioglu M (1984) Effect of sleep deprivation on sleep and EEG power spectra in the rat. Behav Brain Res 14:171–182PubMedCrossRefGoogle Scholar
  55. 55.
    Franken P, Dijk D-J, Tobler I, Borbély AA (1991) Sleep deprivation in rats: effects on EEG power spectra, vigilance states and cortical temperature. Am J Physiol 261:R198–R208PubMedGoogle Scholar
  56. 56.
    Amici R, Zamboni G, Perez E, Jones CA, Toni I, Culin F, Parmeggiani PL (1994) Pattern of desynchronized sleep during deprivation and recovery induced in the rat by changes in ambient temperature. J Sleep Res 3:250–256PubMedCrossRefGoogle Scholar
  57. 57.
    Trachsel L, Tobler I, Acherman P, Borbély A (1991) Sleep continuity and the REM-nREM cycle in the rat under baseline conditions and after sleep deprivation. Physiol Behav 49:575–580PubMedCrossRefGoogle Scholar
  58. 58.
    Kripke DF, Reite ML, Pegram LM, Stephens LM, Lewis OF (1968) Nocturnal sleep in rhesus monkeys. Electroencephalogr Clin Neurophysiol 24:582–586PubMedGoogle Scholar
  59. 59.
    Ursin R (1970) Sleep stage relations within the sleep cycles of the cat. Brain Res 20:91–97PubMedCrossRefGoogle Scholar
  60. 60.
    Kobayashi T, Tsuji Y, Endo S (1985) Sleep cycles as a basic unit of sleep. In: Schultz H, Lavie P (eds) Ultradian rhythms in physiology and behavior. Exp Brain Res suppl 12. Springer-Verlag, Berlin Heidelberg, pp 260–269CrossRefGoogle Scholar
  61. 61.
    Merica H, Gaillard JM (1991) A study of the interrupted REM episode. Physiol Behav 50:1153–1159PubMedCrossRefGoogle Scholar
  62. 62.
    Amici R, Zamboni G, Perez E, Jones CA, Parmeggiani PL (1997) The influence of a heavy thermal load on REM sleep in the rat. Brain Res (submitted)Google Scholar
  63. 63.
    Sakaguchi S, Gltozbach SF, Heller HC (1979) Influence of hypothalamic and ambient temperatures on sleep in kangaroo rats. Am J Physiol 237:R80–R88PubMedGoogle Scholar
  64. 64.
    Roussel B, Turrillot P, Kitahama K (1984) Effect of ambient temperature on sleep-waking cycle in two strains of mice. Brain Res 294:67–73PubMedCrossRefGoogle Scholar
  65. 65.
    Sichieri R, Schmidek WR (1984) Influence of ambient temperature on the sleep-wakefulness cycle in the golden hamster. Physiol Behav 33:871–877PubMedCrossRefGoogle Scholar
  66. 66.
    Parmeggiani PL, Cianci T, Calasso M, Zamboni G, Perez E (1980) Quantitative analysis of short term deprivation and recovery of desynchronized sleep in cats. Electroencephalogr Clin Neurophysiol 50:293–302PubMedCrossRefGoogle Scholar
  67. 67.
    Siegel GJ, Agranoff BW, Albers RW, Molinoff PB (1994) Basic neurochemistry. Raven, New YorkGoogle Scholar
  68. 68.
    Cooper DMF, Mons N, Karpen JW (1995) Adenylyl cyclases and the interreaction between calcium and cAMP signalling. Nature 374:421–424PubMedCrossRefGoogle Scholar
  69. 69.
    Mons M, Cooper D (1995) Adenylate cyclases: critical foci in neuronal signaling. Trends Neurosci 18:536–542PubMedCrossRefGoogle Scholar
  70. 70.
    Sutherland EW (1972) Studies on the mechanism of hormone action. Science 177:401–408PubMedCrossRefGoogle Scholar
  71. 71.
    Beavo JA (1995) Cyclic nucleotide phosphodiesterases functional implications of multiple isoforms. Physiol Rev 75:725–748PubMedGoogle Scholar
  72. 72.
    Francis SH, Corbin JD (1994) Structure and function of cyclic nucleotide-dependent protein kinases. Annu Rev Physiol 56:237–272PubMedCrossRefGoogle Scholar
  73. 73.
    Zimmerman AL (1995) Cyclic nucleotide gated channels. Curr Opin Neurobiol 5:296–303PubMedCrossRefGoogle Scholar
  74. 74.
    Hunter T (1995) Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80:225–236PubMedCrossRefGoogle Scholar
  75. 75.
    Jessel TM, Kandel ER (1993) Synaptic transmission: a bidirectional and self-modifiable form of cell-cell communication. Cell 72/ Neuron 10[Suppl]: 1–30CrossRefGoogle Scholar
  76. 76.
    Steriade M (1994) Brain electrical activity and sensory processing during waking and sleep states. In: Kryger MH, Roth T, Dement WE (eds) Principles and practice of sleep medicine. WB Saunders, London, pp 105–124Google Scholar
  77. 77.
    Perez E, Zamboni G, Amici R, Fadiga L, Parmeggiani PL (1991) Ultradian and circadian changes in the cAMP concentration in the preoptic region of the rat. Brain Res 551:132–135PubMedCrossRefGoogle Scholar
  78. 78.
    Perez E, Zamboni G, Amici R, Jones CA, Parmeggiani PL (1995) cAMP accumulation in the hypothalamus, cerebral cortex, pineal gland and brown fat across the wake-sleep cycle of the rat exposed to different ambient temperatures. Brain Res 684:56–60PubMedCrossRefGoogle Scholar
  79. 79.
    Perez E, Zamboni G, Parmeggiani PL (1982) cAMP concentration in the rat’s preoptic region and cerebral cortex during sleep deprivation and recovery induced by ambient temperature. Exp Brain Res 47:114–118PubMedCrossRefGoogle Scholar
  80. 80.
    Zamboni G, Perez E, Parmeggiani PL (1982) Cyclic AMP concentration in the rat’s preoptic region. Experientia 38:1188–1189PubMedCrossRefGoogle Scholar
  81. 81.
    Zamboni G, Jones CA, Amici R, Perez E, Parmeggiani PL (1996) The capacity to accumulate cyclic AMP in the preoptic-anterior hypothalamic area of the rat is affected by the exposition to low ambient temperature and the subsequent recovery. Exp Brain Res 109:164–168PubMedCrossRefGoogle Scholar
  82. 82.
    Gross RA, Ferrendelli JA (1980) Mechanisms of cyclic AMP regulation in cerebral anoxia and their relationship to glycogenolysis. J Neurochem 34:1309–1318PubMedCrossRefGoogle Scholar
  83. 83.
    Zamboni G, Perez E, Amici R, Parmeggiani PL (1990) The short-term effects of dl-propranolol on the wake-sleep cycle of the rat are related to selective changes in preoptic cyclic AMP concentration. Exp Brain Res 81:107–112PubMedCrossRefGoogle Scholar
  84. 84.
    Perez E, Amici R, Bacchelli B, Zamboni G, Libert JP, Parmeggiani PL (1987) Kinetic parameters of tyrosine hydroxylase activity during sleep deprivation and recovery induced by ambient temperature. Sleep 10:436–442PubMedGoogle Scholar
  85. 85.
    Morgan JI, Curran T (1991) Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu Rev Neurosci 14:421–451PubMedCrossRefGoogle Scholar
  86. 86.
    Pompeiano M, Cirelli C, Tononi G (1992) Effects of sleep deprivation on Fos-like immunoreactivity in the rat brain. Arch Ital Biol 130:325–335PubMedGoogle Scholar
  87. 87.
    Pompeiano M, Cirelli C, Tononi G (1994) Immediate-early genes in spontaneous wakefulness and sleep: expression of c-fos and NGFI-A mRNA and protein. J Sleep Res 3:80–96PubMedCrossRefGoogle Scholar
  88. 88.
    O’Hara BF, Young KA, Watson FL, Heller HC, Kilduff TS (1993) Immediate early gene expression in brain during sleep deprivation: preliminary observations. Sleep 16:1–7PubMedGoogle Scholar
  89. 89.
    Sherin JE, Shiromani PJ, McCarley RW, Saper CB (1996) Activation of ventrolateral preoptic neurons during sleep. Science 271:216–221PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia, Milano 1997

Authors and Affiliations

  • G. Zamboni
    • 1
  • E. Perez
    • 1
  • R. Amici
    • 1
  1. 1.Dipartimento di Fisiologia Umana e GeneraleUniversità di BolognaBolognaItaly

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