Biochemical Approach to the Wake-Sleep Cycle

  • G. Zamboni
  • E. Perez
  • R. Amici


The biochemistry of waking and sleeping processes seems to engulf the whole of the brain’s functions; the molecular description of the mechanisms involved constitutes one of the most fundamental explanatory levels available. In the case of the wake-sleep cycle, the gap in knowledge existing between molecules and these behavioural states has been filled on the assumption that wake-sleep processes are the expression of some general function concerning both the brain and the body, and thus, both widespread neuronal and humoral influences have been investigated. Both pathways imply that neuronal or non-neuronal cells release substances which control the behavioural states of waking and sleeping by acting on regulatory centres. However, there are two tasks that should be fulfilled in order to clarify how the control of waking and sleeping is organized at the molecular level: the first is to identify the substance(s) involved and the other is to assess the location(s) of their effects, that is, the components of the nervous circuit involved in the control.


Sleep Deprivation cAMP Concentration NREM Sleep Biochemical Approach American Physiological Society 
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Copyright information

© Springer-Verlag Italia, Milano 1997

Authors and Affiliations

  • G. Zamboni
    • 1
  • E. Perez
    • 1
  • R. Amici
    • 1
  1. 1.Dipartimento di Fisiologia Umana e GeneraleUniversità di BolognaBolognaItaly

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