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Statics of the respiratory system

  • E. D’Angelo
Part of the Topics in Anaesthesia and Critical Care book series (TIACC)

Abstract

The statics of the respiratory system and its component parts are studied by determining and analyzing the corresponding volume-pressure relationships. These relationships are usually represented as single lines, implying that: a) static pressures depend on volume alone; and b) pressure across any respiratory structure can be dealt with as a single value. Neither of these assumptions is, however, correct. In fact, static pressures differ depending on the volume and time history of the respiratory system. For example, static curves obtained as volume is changed in progressive steps from residual volume to total lung capacity and back again are loops, called “hysteresis loops”. Static or quasi-static (i.e. long-term) elastic hysteresis is a common phenomenon exhibited by the various tissues of the body [1]. In the respiratory system it is attributed to both viscoelasticity, such as stress adaptation, i.e. a rate-dependent phenomenon, and plasticity, i.e. a rate-independent phenomenon. This relates partly to the definition chosen to qualify static conditions, and partly to the technical difficulties encountered in order to satisfy that definition, particularly in in vivo studies. Indeed only plasticity should be held responsible for hysteresis which, in a mechanical analogue, would occur only in the presence of dry friction. There is no information concerning pressure related to tissue plasticity in humans; however, it has been suggested that this pressure component should be very small in the tidal volume range [2].

Keywords

Respiratory System Lung Volume Lower Body Negative Pressure Erect Posture Muscular Paralysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Remington JW (1955) Hysteresis loop behavior of the aorta and other extensible tissues. Am J Physiol 180:83–95PubMedGoogle Scholar
  2. 2.
    Jonson B, Beydon L, Brauer K, Manson C, Valid S, Grytzell H (1993) Mechanics of respiratory system in healthy anesthetized humans with emphasis on viscoelastic properties. J Appl Physiol 75:132–140PubMedGoogle Scholar
  3. 3.
    Agostoni E (1972) Mechanics of the pleural space. Physiol Rev 52:57–128PubMedGoogle Scholar
  4. 4.
    Heaf PJD, Prime FJ (1956) The compliance of the thorax in normal human subjects. Clin Sei 15:319–327Google Scholar
  5. 5.
    Agostoni E, Hyatt R (1986) Static behavior of the respiratory system. In: Macklem PT, Mead J (eds) Handbook of Physiology. The respiratory system. Mechanics of breathing. Vol III. American phisiological society, Bethesda, pp 113–130Google Scholar
  6. 6.
    D’Angelo E (1984) Techniques for studying the mechanics of the pleural space. In: Otis AB (ed) Techniques in life science. Vol. P415. Elsevier, Amsterdam, pp 1–32Google Scholar
  7. 7.
    Milic-Emili J (1984) Measurements of pressures in respiratory physiology. In: Otis AB (ed) Techniques in Life Science. Vol. P412. Elsevier, Amsterdam, pp 1–22Google Scholar
  8. 8.
    Wade OL (1954) Movements of the thoracic cage and diaphragm in respiration. J Physiol 124:193–212PubMedGoogle Scholar
  9. 9.
    Agostoni E, Mognoni P, Torri G, Saracino F (1965) Relation between changes of rib cage circumference and lung volume. J Appl Physiol 20:1179–1186Google Scholar
  10. 10.
    Strohl KP, Mead J, Banzett RB, Loring SH, Kosch PC (1981) Regional differences in abdominal muscle activity during various maneuvers in humans. J Appl Physiol 51:1471–1476PubMedGoogle Scholar
  11. 11.
    Konno K, Mead J (1967) Measurement of the separate volume changes of rib cage and abdomen during breathing. J Appl Physiol 22:407–422PubMedGoogle Scholar
  12. 12.
    Konno K, Mead J (1968) Static volume-pressure characteristics of the rib cage and abdomen. J Appl Physiol 24:544–548PubMedGoogle Scholar
  13. 13.
    Mead J (1981) Mechanics of the chest wall. In: Hutas I, Debreczeni LA (eds) Advances in physiological sciences. Vol 10. Pergamon Press, Oxford, pp 3–11Google Scholar
  14. 14.
    Macklem PT, Macklem DM, De Troyer A (1983) A model of inspiratory muscle mechanics. J Appl Physiol 55:547–557PubMedGoogle Scholar
  15. 15.
    Hillman DR, Markos J, Finucane K (1990) Effect of abdominal compression on maximum transdiaphragmatic pressure. J Appl Physiol 68:2296–2304PubMedCrossRefGoogle Scholar
  16. 16.
    Boynton BR, Barnas GM, Dadmun JT, Fredberg JJ (1991) Mechanical coupling of the rib cage, abdomen, and diaphragm through their area of apposition. J Appl Physiol 70:1235–1244PubMedCrossRefGoogle Scholar
  17. 17.
    Agostoni E, Gurtner G, Torri C, Rahn H (1966) Respiratory mechanics during submersion and negative-pressure breathing. J Appl Physiol 21:251–258PubMedGoogle Scholar
  18. 18.
    Deschamps C, Rodarte JR, Wilson TA (1988) Coupling between rib cage and abdominal compartments of the relaxed chest wall. J Appl Physiol 65:2265–2269PubMedGoogle Scholar
  19. 19.
    Zechman FW, Musgrave FS, Mains RC, Cohn JB (1967) Respiratory mechanics and pulmonary diffusing capacity with lower body negative pressure. J Appl Physiol 22:247–250PubMedGoogle Scholar
  20. 20.
    D’Angelo E, Sant’Ambrogio G (1974) Direct action of the contracting diaphragm on the rib cage in rabbits and dogs. J Appl Physiol 36:715–719PubMedGoogle Scholar
  21. 21.
    Danon J, Druz WS, Goldberg NB, Sharp JT (1979) Function of isolated paced diaphragm and cervical accessory muscles in CI quadriplegics. Am Rev Respir Dis 119:909–919PubMedGoogle Scholar
  22. 22.
    D’Angelo E (1981) Cranio-caudal rib cage distortion with increasing inspiratory airflow in man. Respir Physiol 44:215–237PubMedCrossRefGoogle Scholar
  23. 23.
    Crawford ABH, Dodd D, Engel LA (1983) Change in rib cage shape during quiet breathing, hyperventilation and single inspirations. Respir Physiol 54:197–209PubMedCrossRefGoogle Scholar
  24. 24.
    McCool FD, Loring SH, Mead J (1985) Rib cage distortion during voluntary and involuntary breathing acts. J Appl Physiol 58:1703–1712PubMedGoogle Scholar
  25. 25.
    Jiang J, Demedts M, Decramer M (1998) Mechanical coupling of upper and lower canine rib cages and its functional significance. J Appl Physiol 64:620–626Google Scholar
  26. 26.
    D’Angelo E, Michelini S, Miserocchi G (1973) Local motion of the chest wall during passive and active expansion. Respir Physiol 19:47–59PubMedCrossRefGoogle Scholar
  27. 27.
    Reid MB, Loring SH, Banzett RB, Mead J (1986) Passive mechanics of upright human chest wall during immersion from hips to neck. J Appl Physiol 60:1561–1570PubMedGoogle Scholar
  28. 28.
    Ward ME, Ward JW, Macklem PT (1992) Analysis of human chest wall motion using a two-compartment rib cage model. J Appl Physiol 72:1338–1347PubMedGoogle Scholar
  29. 29.
    Needham CB, Rogan MC, McDonald I (1954) Normal standard for lung volumes, intrapulmonary gas mixing and maximum breathing capacity. Thorax 9:313–325PubMedCrossRefGoogle Scholar
  30. 30.
    Pierce JA, Ebert RV (1958) The elastic properties of the lungs in the aged. J Lab Clin Med 51:63–71PubMedGoogle Scholar
  31. 31.
    Turner JM, Mead J, Wohl MB (1968) Elasticity of human lungs in relation to age. J Appl Physiol 25:664–671PubMedGoogle Scholar
  32. 32.
    Frank NR, Mead J, Ferris BC Jr (1957) The mechanical behaviour of the lungs in healthy elderly persons. J Clin Invest 36:1680–1687PubMedCrossRefGoogle Scholar
  33. 33.
    Gibson CJ, Pride NB, O’Cain C, Quagliato R (1976) Sex and age differences in pulmonary mechanics in normal nonsmoking subjects. J Appl Physiol 41:20–25PubMedGoogle Scholar
  34. 34.
    Duomarco JL, Rimini R (1947) La presion intrabdominal en el hombre. El Ateneo, Buenos AiresGoogle Scholar
  35. 35.
    Hedenstierna C, Bindslev L, Santesson J, Norlander DP (1981) Airway closure in each lung of anesthetized human subjects. J Appl Physiol 50:55–64PubMedGoogle Scholar
  36. 36.
    Rehder K, Marsh M (1986) Respiratory mechanics during anesthesia and mechanical ventilation. In: Macklem PT, Mead J (eds) The respiratory system. Mechanics of breathing. Handbook of physiology. Vol III. American Physiological Society, Bethesda, pp 737–752Google Scholar
  37. 37.
    Rehder K, Sittipong R, Sessler AD (1972) The effects of thiopental-meperidine anesthesia with succinylcholine paralysis on functional residual capacity and dynamic lung compliance in normal sitting man. Anesthesiology 37:395–398PubMedCrossRefGoogle Scholar
  38. 38.
    Muller N, Volgyesi G, Becker L, Bryan MH, Bryan AC (1979) Diaphragmatic muscle tone. J Appl Physiol 47:279–284PubMedGoogle Scholar
  39. 39.
    Druz WS, Sharp JT (1981) Activity of respiratory muscles in upright and recumbent humans. J Appl Physiol 51:1552–1561PubMedGoogle Scholar
  40. 40.
    Krayer S, Rehder K, Beck KC, Cameron PD, Didier EP, Hoffman EA (1987) Quantification of thoracic volumes by three-dimensional imaging. J Appl Physiol 62:591–598PubMedCrossRefGoogle Scholar
  41. 41.
    Krayer S, Rehder K, Vettermann J, Didier EP, Ritman FL (1989) Position and motion of the human diaphragm during anesthesia-paralysis. Anesthesiology 70:891–898PubMedCrossRefGoogle Scholar
  42. 42.
    Drummond GB, Allan PL, Logan MR (1986) Changes in diaphragmatic position in association with the induction of anaesthesia. Br J Anaesth 58:1246–1251PubMedCrossRefGoogle Scholar
  43. 43.
    Freund F, Roos A, Dodd RB (1964) Expiratory activity of the abdominal muscles in man during general anesthesia. J Appl Physiol 19:693–697PubMedGoogle Scholar
  44. 44.
    Westbrook PR, Stubbs SE, Sessler AD, Rehder K, Hyatt RE (1973) Effects of anesthesia and muscle paralysis on respiratory mechanics in normal man. J Appl Physiol 34:81–86PubMedGoogle Scholar
  45. 45.
    Vellody VP, Nassery M, Dius WS, Sharp JT (1978) Effects of body position change on thoracoabdominal motion. J Appl Physiol 45:581–589PubMedGoogle Scholar
  46. 46.
    Hedenstierna G, Löfström B, Lundh R (1981) Thoracic gas volume and chest- abdomen dimensions during anesthesia and muscle paralysis. Anesthesiology 55:499–506PubMedGoogle Scholar
  47. 47.
    Hedenstierna G, Strandberg A., Brismar B., Lundquist H, Svensson L, Tokics L (1985) Functional residual capacity, thoracoabdominal dimensions, and central blood volume during general anesthesia with muscle paralysis and mechanical ventilation. Anesthesiology 62:247–254PubMedCrossRefGoogle Scholar
  48. 48.
    Rehder K, Mallow JE, Fibuch EE, Krabill DR, Sessler AD (1974) Effects of isoflurane anesthesia and muscle paralysis on respiratory mechanics in normal man. Anesthesiology 41:477–485PubMedCrossRefGoogle Scholar
  49. 49.
    Kimball WR, Loring SH, Basta SJ, De Troyer A, Mead J (1985) Effects of paralysis with pancuronium on chest wall statics in awake humans. J Appl Physiol 58:1638–1645PubMedGoogle Scholar
  50. 50.
    D’Angelo E, Robatto F, Calderini E, Tavola M, Bono D, Milic-Emili J (1991) Pulmonary and chest wall mechanics in anesthetized paralyzed humans. J Appl Physiol 70:2602–2610PubMedGoogle Scholar
  51. 51.
    Brismar B, Hedenstierna G, Lundquist H, Strandberg A, Svensson L, Tokics L (1985) Pulmonary densities during anesthesia with muscular relaxation. A proposal of atelectasis. Anesthesiology 62:422–428PubMedCrossRefGoogle Scholar
  52. 52.
    D’Angelo E, Calderini E, Tavola M, Bono D, Milic-Emili J (1992) Effect of PEEP on respiratory mechanics in anesthetized paralyzed humans. J Appl Physiol 73:1736–1742PubMedGoogle Scholar
  53. 53.
    Goldberg HS, Mitzner W, Adams K, Menkes H, Lichtenstein S, Permutt S (1975) Effect of intrathoracic pressure on pressure-volume characteristics of the lung in man. J Appl Physiol 38:411–417PubMedGoogle Scholar
  54. 54.
    Hillman DR, Finucane KE (1983) The effect of hyperinflation on lung elasticity in healthy subjects. Respir Physiol 54:295–305PubMedCrossRefGoogle Scholar
  55. 55.
    Duggan CJ, Castle WD, Berend N (1990) Effects of continuous positive airway pressure breathing on lung volume and distensibility. J Appl Physiol 68:1121–1126PubMedGoogle Scholar
  56. 56.
    Young SL, Tierney DF, Clements JA (1970) Mechanism of compliance change in excised rat lungs at low transpulmonary pressure. J Appl Physiol 29:780–785PubMedGoogle Scholar
  57. 57.
    Sharp JT, Johnson FN, Goldberg NB, Van Lith P (1967) Hysteresis and stress adaptation in the human respiratory system. J Appl Physiol 23:487–497PubMedGoogle Scholar
  58. 58.
    Rehder K, Knopp TJ, Sessler AD (1978) Regional intrapulmonary gas distribution in awake and anesthetized-paralyzed prone man. J Appl Physiol 45:528–535PubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia, Milano 1999

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  • E. D’Angelo

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