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Partitioning of lung responses into airway and tissue components

  • M. S. Ludwig
Part of the Topics in Anaesthesia and Critical Care book series (TIACC)

Abstract

This chapter deals with the role of the lung parenchyma in contributing to the contractile response of the overall lung during induced constriction. Addressing the contribution of the parenchyma has been made easier in recent years because of the development of the alveolar capsule technique which permits direct measurement of alveolar pressure [1]. Resistive losses across the lung can, thereby, be partitioned into a component due to airway resistance (Raw) and a component due to tissue resistance (Rti). Similarly, resistance changes during induced constriction can be apportioned into the component related to changes in airway calibre and the component related to alterations in tissue mechanical behaviour. Recent studies in a number of different animal species have shown that much of the resistive pressure drop across the lung under baseline conditions is due to the resistive pressure drop at the level of the lung tissues [2-6]. Furthermore, numerous animal studies have now shown that increases in lung resistance (RL) during exogenous or endogenous constriction are due, in large part, to changes in tissue resistance [2, 5-10]. Traditionally, changes in lung resistance with induced constriction were thought to be due to changes in airway calibre. However, if increases in tissue resistance account for a large part of the increase in lung resistance, then the pathophysiology of diseases such as asthma needs to be reconsidered.

Keywords

Vagal Stimulation Tissue Resistance Alveolar Pressure Late Asthmatic Response Lung Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia, Milano 1999

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  • M. S. Ludwig

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