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Oxygen Delivery and Consumption Relationships in Sepsis — The Role of Inotropic and Vasoactive Drugs

Conference paper

Abstract

Oxygen delivery (DO2) and oxygen consumption (\( \mathop \text{V}\limits^\text{.} \)O2) relationships are a confusing subject with contradictory research findings. Whole body DO2, also termed oxygen availability, is calculated: DO2 = Hb x SaO2 x CO x 0.134, where Hb = hemoglobin concentration, g/dl; SaO2 = arterial oxygen saturation, %; CO = cardiac output, 1/min. \( \mathop \text{V}\limits^\text{.} \)O2 can either be calculated indirectly, Hb x (SaO2 — SvO2) X CO X 0.134, where SvO2 = venous oxygen saturation, or be directly measured as the difference between inspired and expired gases. In normal individuals \( \mathop \text{V}\limits^\text{.} \)O2 is closely regulated to provide for the bodies needs and remains relatively constant over a wide range of DO2. If DO2 falls however, a critical point is reached after which \( \mathop \text{V}\limits^\text{.} \)O2 also falls. A different situation might occur in critically ill patients, particularly septic patients, where \( \mathop \text{V}\limits^\text{.} \)O2 appears to be related to DO2 over a wide range of DO2, a phenomenon termed “supply dependence” [1].

Keywords

Septic Shock Methylene Blue Severe Sepsis Septic Patient Oxygen Delivery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia, Milano 1998

Authors and Affiliations

  • O. Boyd

There are no affiliations available

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