Modulating Prostaglandin Metabolism in Sepsis

  • M. R. Pinsky
Conference paper


Sepsis is associated with a cacophony of activation and inhibition of numerous aspects of the host’s inflammatory pathways. Because sepsis is usually initiated by pro-inflammatory stimuli such as pancreatitis, trauma, endotoxemia numerous studies have focused on anti-inflammatory therapies in the management of patients with sepsis and septic shock. The mechanisms by which these initiating processes induce inflammation and their regulation are central to this mind set.


Blood Lactate Level Endotoxic Shock White Blood Cell Count Count Endotoxin Infusion Multiple System Organ Failure 
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© Springer-Verlag Italia, Milano 1998

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  • M. R. Pinsky

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