Abstract
Sepsis is associated with a cacophony of activation and inhibition of numerous aspects of the host’s inflammatory pathways. Because sepsis is usually initiated by pro-inflammatory stimuli such as pancreatitis, trauma, endotoxemia numerous studies have focused on anti-inflammatory therapies in the management of patients with sepsis and septic shock. The mechanisms by which these initiating processes induce inflammation and their regulation are central to this mind set.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Weil MH, MacLean LD, Vischer MB et al (1959) Studies on the circulatory changes in the dog produced by gram-negative microorganisms. J Clin Invest 35:1191–1198
Kunkel SL, Spengler M, May MA et al (1988) Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression. J Biol Chem 263:5380–5384
Okusawa S, Gelfand JA, Ikejima T et al (1988) Interleukin-1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effects of cyclooxygenase inhibition. J Clin Invest 81:1162–1172
Ertel W, Morrison MH, Ayala A, Chaudry IH (1991) Eicosanoids regulate tumor necrosis factor synthesis after hemorrhage in vitro and in vivo. J Trauma 31:609–615
Martich GD, Danner RL, Ceska M, Suffredini AF (1991) Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of anti-inflammatory agents. J Exp Med 173:1021–1024
Beutler B, Krochin N, Milsark IW et al (1986) Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science 232:977–980
Dinarello CA, Cannon JG, Wolff SM et al (1986) Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. J Exp Med 163:1433–1450
Tracey KJ, Beutler B, Lowry SF et al (1986) Shock and tissue injury induced by recombinant human cachectin. Science 234:470–474
Fletcher JR (1982) The role of prostaglandins in sepsis. Scand J Infect Dis Suppl 31:55–60
Calandra T, Gerain J, Heumann D et al (1991) High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines. Am J Med 91:23–29
Preiser JC, Schmartz D, Van der Linden P et al (1991) Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog. Cytokine 3:1–4
Pinsky MR, Vincent JL, Deviere J et al (1993) Serum cytokine levels in human septic shock: relation to multiple systems organ failure and mortality. Chest 103:565–575
Rosenbloom A, Pinsky MR, Bryant JL et al (1995) Leukocyte activation in the peripheral blood of patients with cirrhosis of the liver and SIRS: Correlation with serum Interleukin-6 levels and organ dysfunction. JAMA 274:58–65
Northover BJ, Subramanian G (1982) Analgesic-antipyruvate drugs as antagonists of endotoxic shock in dogs. J Pathol 83:463–471
Leeper-Woodford SK, Carey PD, Byrne K et al (1991) 3rd: Ibuprofen attenuates plasma tumor necrosis factor activity during sepsis-induced acute lung injury. J Appl Physiol 71:915–923
Kettelhut IC, Fiers W, Goldberg AL (1987) The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors. Proc Natl Acad Sei USA 84:4273–4277
Knudsen PJ, Dinarello CA, Strom TB (1986) Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenoside monophosphate. J Immunol 137:3189–3194
Ahmed T, Weichman B, Wasserman MA et al (1988) Prevention and reversal of endotoxin- induced pulmonary hypertension by a leukotriene antagonist. Eur Respir J 1:142–152
Matuschak GM, Pinsl MR, Klein EC et al (1990) Effects of D-galactosamine-induced acute liver injury on mortality and pulmonary responses to Escherichia coli lipopolysaccharide. Modulation by arachidonic acid metaboUtes. Am Rev Respir Dis 141:1296–1306
Van Snick J, Cayphas S, Vink A et al (1986) Purification and NHj-teraiinal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas. Proc Natl Acad Sci USA 83:9679–9683
Pinsky MR (1992) The cardiovascular response in canine endotoxic shock: eiffect of ibuprofen pretreatment. Circ Shock 37:323–332
Pinsky MR, Matuschak GM (1986) Cardiovascular determinants of the hemodynamic response to acute endotoxemia in the dog. J Crit Care 1:18–31
Vincent JL, Roman A, De Backer D, Kahn RJ (1990) Oxygen uptake/supply dependency. Effects of short-term dobutamine infusion. Am Rev Respir Dis 142:2–7
BaUc RA, Jacobs RF, Tryka AF et al (1988) Low dose ibuprofen reverses the hemodynamic alterations of canine endotoxin shock. Crit Care Med 16:1128–1131
Galanos C, Freudenberg MA, Reutter W (1979) Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci USA 76:5939–5943
Ogletree ML (1987) Overview of physiological and pathophysiological effects of thromboxane A2. Fed Proc 46:133–138
Jacobs ER, Soulsby ME, Bone RC et al (1982) Ibuprofen in canine endotoxin shock. J Clin Invest 70:536–541
Kadowitz PJ, Chapnick BM, Joiner PD, Hyman AL (1975) Influence of inhibitors of prostaglandin synthesis on the canine pulmonary vascular bed. Am J Physiol 229:941–946
Ahmed T, D’Brot J, Weasserman MA et al (1988) Effect of Verapamil on pulmonary and eicosanoid responses to endotoxin in awake sheep. J Appl Physiol 64:1700–1708
Balk RA, Jacobs RF, Tryka AF et al (1988) Effects of ibuprofen on neutrophil function and acute lung injury in canine endotoxin shock. Crit Care Med 16:1121–1127
Spinas GA, Bloesch D, Keller U et al (1991) Pretreatment with ibuprofen augments circulating tumor necrosis factor-alpha, interleukin-6, and elastase during acute endotoxinemia. J Infect Dis 163:89–95
Mathews WR, Murphy RC (1982) Inhibition of leukotriene biosynthesis in mastocytoma cells by diethylcarbamazine. Biochem Pharmacol 31:2129–2132
Schmand JF, Ayala A, Morrison MH, Chaudry IH (1995) Effects of hydroxyethyl starch after trauma-hemorrhagic shock: restoration of macrophage integrity and prevention of increased circulating interieukin-6 levels. Crit Care Med 23:806–814
Kilboum RO, Gross SS, Jubran A et al (1990) N-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide. Proc Natl Acad Sci USA 87:3629–3632
Rosenbloom A, Pinsky MR, Bryant JL et al (1995) Leukocyte Activation in the Peripheral Blood of Patients With Cirrhosis of the Liver and SIRS: Correlation With Serum Interleukin-6 Levels and Organ Dysfunction. JAMA 274:58–65
Bernard GR, Wheeler AP, Russel JA et al (1997) The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med 336: 912–918
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Italia, Milano
About this paper
Cite this paper
Pinsky, M.R. (1998). Modulating Prostaglandin Metabolism in Sepsis. In: Baue, A.E., Berlot, G., Gullo, A. (eds) Sepsis and Organ Dysfunction. Springer, Milano. https://doi.org/10.1007/978-88-470-2271-3_8
Download citation
DOI: https://doi.org/10.1007/978-88-470-2271-3_8
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0297-5
Online ISBN: 978-88-470-2271-3
eBook Packages: Springer Book Archive