Abstract
Sepsis may be defined as a systemic inflammatory response to an infection. The syndrome is characterized by alterations in temperature, leukocytosis, hypotension, hypoperfusion with cellular injury and organ failure often resulting in death.
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References
Kreger BE, Craven DE, McCabe WR (1980) Gram negative bacteremia IV. Re-evaluation of clinical features and treatments in 612 patients. Am J Med 68:344–355
Fujishima S, Aikawa N (1995) Neutrophil-mediated tissue injury and its modulation. Intensive Care Med 21:277–285
Levi M, ten Cate H, van der Poll T, van Deventer SJH (1993) Pathogenesis of disseminated intravascular coagulation in sepsis. JAMA 270:975–979
Gamble JR, Harlan JM, Klebanoff SJ, Vadas MA (1985) Stimulation of the adherence of neutrophils to umbilical vein endothelium by recombinant TNF. Proc Natl Acad Sci USA 82: 8667–8671
Verheij M, Bose R, Xin HL et al (1996) Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380:75–79
Michie HR, Manogue KR, Spriggs DR et al (1988) Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 318:1481–1486
Matrich GD, Danner RL, Ceska M, Suffredini AF (1991) Detection of IL-8 and TNF in normal humans after intravenous endotoxin. The effect of anti-inflammatory agents. J Exp Med 173:1021–1024
Sylvester I, Cuffredini AF, Boujoukos AJ et al (1993) Neutrophil attractant protein 1 and monocyte chemoattractant protein 1 in human serum. J Immunol 151:3292–3298
Van der Poll T, Levi M, van Deventer SHJ et al (1994) Differential effects of anti-TNF antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees. Blood 83:446–451
Van der Poll, Levi M, Hack Ce et al (1994) EUmination of IL-6 attenuates coagulation activation in experimental endotoxemia in chimpazees. J Exp Med 179:1253–1259
Raponi G, Antonelli M, Gaeta G et al (1992) TNF in serum and in BAL of patients at risk for ARDS. J Crit Care 7:183–188
Finn A, Naik S, Klein N et al (1993) Interleukin-8 release and neutrophil degranulation after paediatric cardiopulmonary bypass. J Thorac Cardiovasc Surg 105:234–241
Bauer J, Herrmann F (1991) Interleukin-6 in clinical medicine. Ann Hematol 62:203–207
Antonelli M, Raponi GM, Martino P et al (1995) High IL-6 serum levels are associated with septic shock with severe leukopenia due to malignancies. Scand J Infect Dis 27:381–384
Suffredini AF, Reda D, Banks SM et al (1995) Effects of recombinant dimeric TNF receptors on human inflammatory responses following intravenous endotoxin administration. J Immunol 155:5038–5045
Von der Mohlen MAM, Kimmings NA, Wedel N et al (1995) Inhibition of endotoxin-induced cytokine release and neutrophil activation in human using a recombinant endotoxin binding protein (rBPI23). J Infect Dis 172:144–151
Gorgen I, Härtung T, Leist M et al (1991) Granulocyte colony-stimulating factor treatment protects rodents against LPS-induced toxicity via suppression of systemic TNF alpha. J Immunol 149:918–924
Sartorelli KH, Silver GM, Gamelli RL (1991) The effect of C-GSF upon bum-induced defective neutrophil Chemotaxis. J Trauma 31:523–529
Nelson S, Parkas S, Fotheringham N et al (1996) Filgrastin in the treatment of hospitalized patients with community acquired pneumonia. Am J Respir Crit Care Med 153 (abs)
Pollmacher T, Korth C, Mullington J et al (1996) Effects of G-CSF on plasma cytokine and cytokine receptor levels and on the vivo host response to endotoxin in healthy men. Blood 87:900–905
Derkx B, Marchant A, Goldman M et al (1995) High levels of IL-10 during the initial phases of fulminant meningococcal septic shock. J Infect Dis 171:229–232
Hun RD, Radwaski E, O’ConneU SM et al (1996) Pharmacokinetics and immunomodulatory properties of intravenous administred recombinant human IL-10 in healthy volunteers. Blood 87:699–705
Schmid-Schonbein GW, Usami S, Skalak R et al (1980) The interaction of leukocytes and erythrocytes in capillary and postcapillary vessels. Microvasc Res 19:45–70
Mayrovitz HN, Rubin R (1985) Leukocyte distribution to arteriolar branches: Dependence on microvascular blood flow. Microvasc Res 29:282–294
Kishimoto TK, Jutiha MA, Berg EL et al (1989) Neutrophil Mac.l and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 245:1238–1241
Anderson DC (1995) The role of Beta 2 integrins and intracellular adhesion molecule type 1 in inflammation. In: Granger DN, Schmid, Schonbein (eds) Physiology and pathophysiology of leukocyte adhesion. 1st edn. Oxford University Press, New York, pp 3–42
Windsor ACJ, Walsh CJ, Mullen PG et al (1993) TNF alpha blockade prevents neutrophil CD 18 receptorupregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation. J Clin Invest 91:1459–1468
Pixley RA, de la Cadena R, Page JD et al (1993) The contact system contributes to hypotension, but not to Die in lethal bacteremia. J Clin Invest 91:61–68
Van der Poll T, Levi M, Hack CE et al (1994) Elimination of IL-6 attenuates coagulation activation in experimental endotoxemia in chimpanzee. J Exp Med 179:1253–1259
Gawaz M, Dickfeld T, Bogner et al (1997) Platelet function in septic multiple organ dysfunction syndrome. Intensive Care Med 23:379–385
Hannun YA, Obeid LM (1995) Ceramide: an intracellular signal for apoptosis. Trends Biochem Sei 20:386–401
Wiegmann K, Scheutze K, Machleidt T et al (1994) Functional dichotomy of neutral and acidic sphingomyelinases in TNF signalling. Cell 78:1005–1015
Teodorczyk-Injeyan JA, Cembrznska-Nowak M, Llani S et al (1995) Immune deficiency following thermal trauma is associated with apoptotic cell death. J Clin Immunol 15:318–328
Chitnis DC, Dickerson C, Munster AM et al (1996) Inhibition of apoptosis in polymorphonuclear neutrophils from bum patients. J Leuk Biol 59:835–839
Bone (1996) Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann Intem Med 125:680–687
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© 1998 Springer-Verlag Italia, Milano
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Antonelli, M., Passariello, M. (1998). Old and New Mediators in Sepsis The Enigma Is Not Yet Resolved. In: Baue, A.E., Berlot, G., Gullo, A. (eds) Sepsis and Organ Dysfunction. Springer, Milano. https://doi.org/10.1007/978-88-470-2271-3_7
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DOI: https://doi.org/10.1007/978-88-470-2271-3_7
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0297-5
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