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Lights and Shadows in Sepsis and Multiple Organ Dysfunction Syndrome (MODS)

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Sepsis and Organ Dysfunction

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Abstract

In the last decade, understanding of the basic pathophysiologic mechanism underlying the development of sepsis and septic shock has made impressive progress. New discoveries have challenged previously accepted concepts of infection and sepsis, and profound revisions and new therapies have been proposed. This scientific revolution led to the implementation of several large clinical trials employing new agents aimed at preventing or blocking the release of mediators involved in the development of the systemic inflammatory response characteristic of sepsis and related disorders, ultimately leading to Multiple Organ Dysfunction Syndrome (MODS). Unfortunately, the overall results indicate that these novel approaches have not been associated with a substantially improved outcome of septic patients, and in many cases both the design and the results of these trials have been criticized [1].

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  1. G. Berlot
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  2. L. Silvestri
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  3. F. Iscra
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  4. G. Sganga
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  5. A. Gullo
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Editors and Affiliations

  1. Department of Surgery, Saint Louis University, Health Sciences Center, St. Louis, USA

    A. E. Baue M.D.

  2. Department of Anaesthesia, Intensive Care and Pain Therapy, University of Trieste, Cattinara Hospital, Trieste, Italy

    G. Berlot M.D.  & A. Gullo M.D.  & 

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Berlot, G., Silvestri, L., Iscra, F., Sganga, G., Gullo, A. (1998). Lights and Shadows in Sepsis and Multiple Organ Dysfunction Syndrome (MODS). In: Baue, A.E., Berlot, G., Gullo, A. (eds) Sepsis and Organ Dysfunction. Springer, Milano. https://doi.org/10.1007/978-88-470-2271-3_16

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  • DOI: https://doi.org/10.1007/978-88-470-2271-3_16

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