SIRS and Sepsis-Induced Neuromuscular Dysfunctions

  • C. F. Bolton
Conference paper


Sepsis [1] has been increasingly associated with a severe systemic response to infection, usually resulting in early death. However, sepsis may be evoked in the absence of infection (e.g. trauma and bums), thus the term “systemic inflammatory response syndrome” or SIRS [2] is now used. Considering the profound changes induced by SIRS, it is not surprising that the nervous system is affected (Fig. 1). The chief manifestations are septic encephalopathy and critical illness polyneuropathy, each occurring in approximately 70% of septic patients [3].


Systemic Inflammatory Response Syndrome Critical Care Unit Neuromuscular Blocking Agent Critical Illness Polyneuropathy Critical Illness Myopathy 
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© Springer-Verlag Italia, Milano 1998

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  • C. F. Bolton

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