Effects of Adrenergic Agents on the Hepato-Splanchnic Circulation: An Update

  • D. De Backer
  • J.-L. Vincent
Conference paper


Recent studies [1, 2] have implicated the hepato-splanchnic area in the development of multiple organ failure. Important alterations can take place in the gut and the liver during sepsis, A decreased gastric intramucosal pH (pHi), thought to reflect inadequate gut perfusion, is often encountered in sepsis and is associated with increased mortality rates [3, 4]. Liver dysfunction is also common in sepsis and alterations in liver blood flow may contribute to it. The hepatic venous oxygen saturation (ShO2) is often decreased [5-9], reflecting an imbalance between oxygen demand and supply in the hepato-splanchnic area. Also, the liver could be a major source of cytokine release [10], possibly triggered by hypoxia.


Septic Shock Septic Patient Respir Crit Mucosal Blood Flow Liver Blood Flow 
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Copyright information

© Springer-Verlag Italia, Milano 1998

Authors and Affiliations

  • D. De Backer
  • J.-L. Vincent

There are no affiliations available

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