Epidemiology and Clinical Course of Sepsis

  • L. Ilkka
  • J. Takala
Conference paper


Sepsis can be broadly defined as the systemic inflammatory response to infection. Sepsis is an important cause of morbidity and mortality in hospitalized patients. In intensive care patients, sepsis is one of the most common causes of prolonged intensive care and death. Accordingly, a sizable proportion of intensive care resources is used to treat patients with sepsis and sepsis-related dysfunction of vital organs. Despite this, the epidemiology and clinical course of sepsis has not been well defined. Lack of uniform definitions and criteria for sepsis has certainly contributed to this lack of information.


Septic Shock Severe Sepsis Systemic Inflammatory Response Syndrome Intensive Care Patient Systemic Inflammatory Response Syndrome Criterion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Wiles JB, Cerra FB, Siegel JH, Border JR (1980) The systemdc septic response: does the organism matter? Crit Care Med 8:55–60PubMedCrossRefGoogle Scholar
  2. 2.
    Parker MM, Shelhamer JH, Natanson C et al (1987) Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: Heart rate as an early predictor of prognosis. Crit Care Med 15:923–929PubMedCrossRefGoogle Scholar
  3. 3.
    Shoemaker WC, Appel PL, Kram HB et al (1993) Sequence of physiologic patterns in surgical septic shock. Crit Care Med 21:1876–1889PubMedCrossRefGoogle Scholar
  4. 4.
    Vincent J-L (1997) Dear SIRS, I’m sorry to say that I don’t like you… Crit Care Med 25: 372–374PubMedCrossRefGoogle Scholar
  5. 5.
    Parrillo JE (1993) Pathogenetic mechanisms of septic shock. New Engl J Med 328:1471–1477PubMedCrossRefGoogle Scholar
  6. 6.
    American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864–874CrossRefGoogle Scholar
  7. 7.
    Increase in national hospital discharge survey rates for septicemia — United States 1979–1987. Morb Mort Weekly Rep 39:31–34Google Scholar
  8. 8.
    Bone RC (1991) The pathogenesis of sepsis. Ann Intern Med 115:457–469PubMedGoogle Scholar
  9. 9.
    Bone RC (1991) Sepsis, the sepsis syndrome, multi-organ failure. A plea for comparable definitions. Ann Intern Med 114:332–333PubMedGoogle Scholar
  10. 10.
    Rackow EC, Astiz ME, Weil MH (1988) Cellular oxygen metabolism during sepsis and shock. The relationship of oxygen consumption to oxygen delivery. JAMA 259:1989–1993PubMedCrossRefGoogle Scholar
  11. 11.
    Marshall JC, Sweeney (1990) Microbial infection and the septic response in critical surgical illness. Sepsis, not infection, determines outcome. Arch Surg 125:17–25PubMedGoogle Scholar
  12. 12.
    Ziegler EJ, Fisher CJ, Sprung CL et al (1991) Treatment of Gram-negative bacteremia and septic shock with HA-IA human monoclonal antibody against endotoxin. A randomized, double-blinded, placebo-controlled trial. New Engl J Med 324:429–436Google Scholar
  13. 13.
    Bone RC, Balk RA, Fein AM et al (1995) A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: Results of a prospective, multicenter, randomized, controlled trial. Crit Care Med 23:994–1006PubMedCrossRefGoogle Scholar
  14. 14.
    Rangel-Frausto MS, Pittet D, Costigan M et al (1995) The natural history of the systemic inflammatory response (SIRS). A prospective study. JAMA 273:117–123Google Scholar
  15. 15.
    Salvo I, de Cian W, Musicco M et al (1995) The Italian sepsis study: Preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock. Int Care Med 21: S244–249CrossRefGoogle Scholar
  16. 16.
    Vincent J-L, Bihari DJ, Suter PM et al (1995) The prevalence of nosocomial infection in intensive care units in Europe. Results of the European prevalence of infection in intensive care (EPIC) study. JAMA 274:639–644PubMedCrossRefGoogle Scholar
  17. 17.
    Brun-Buisson C, Doyon F, Carlet J et al (1995) Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. JAMA 274:968–974PubMedCrossRefGoogle Scholar
  18. 18.
    Wildmer A (1994) Infection control and prevention strategies in the ICU. Int Care Med 20: S7-S11CrossRefGoogle Scholar
  19. 19.
    Pittet D, Brun-Buisson C (1996) Nosocomial infections and the intensivist. Curr Opin Crit Care 2:345–346CrossRefGoogle Scholar
  20. 20.
    Goldstein EJC (1996) Anaerobic bacterenua. Clin Inf Dis 23:S97-S101CrossRefGoogle Scholar
  21. 21.
    Pfaller M, Wenzel R (1992) Impact of the changing epidemiology of fungal infections in the 1990s. Eur J Clin Microbiol Infect Dis 11:287–291PubMedCrossRefGoogle Scholar
  22. 22.
    Girou E, Brun-Buisson C (1996) Morbidity, mortality, and the cost of nosocomial infections in critical care. Curr Opin Crit Care 2:347–351CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia, Milano 1998

Authors and Affiliations

  • L. Ilkka
  • J. Takala

There are no affiliations available

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