Epidemiology and Clinical Course of Sepsis
Sepsis can be broadly defined as the systemic inflammatory response to infection. Sepsis is an important cause of morbidity and mortality in hospitalized patients. In intensive care patients, sepsis is one of the most common causes of prolonged intensive care and death. Accordingly, a sizable proportion of intensive care resources is used to treat patients with sepsis and sepsis-related dysfunction of vital organs. Despite this, the epidemiology and clinical course of sepsis has not been well defined. Lack of uniform definitions and criteria for sepsis has certainly contributed to this lack of information.
KeywordsSeptic Shock Severe Sepsis Systemic Inflammatory Response Syndrome Intensive Care Patient Systemic Inflammatory Response Syndrome Criterion
Unable to display preview. Download preview PDF.
- 7.Increase in national hospital discharge survey rates for septicemia — United States 1979–1987. Morb Mort Weekly Rep 39:31–34Google Scholar
- 12.Ziegler EJ, Fisher CJ, Sprung CL et al (1991) Treatment of Gram-negative bacteremia and septic shock with HA-IA human monoclonal antibody against endotoxin. A randomized, double-blinded, placebo-controlled trial. New Engl J Med 324:429–436Google Scholar
- 14.Rangel-Frausto MS, Pittet D, Costigan M et al (1995) The natural history of the systemic inflammatory response (SIRS). A prospective study. JAMA 273:117–123Google Scholar