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Immune activation in the interface between innate immunity and adaptive response:in vitro studies and therapeutical implications

  • G. Ristori
  • A. Perna
  • C. Montesperelli
  • L. Battistini
  • R. Bomprezzi
  • S. Cannoni
  • G. Borsellino
  • C. Pozzilli
  • C. Buttinelli
  • M. Salvetti
Conference paper

Abstract

In multiple sclerosis (MS), as well as in other putatively T cell mediated diseases, much attention has been devoted to possible dysregulations at the level of the adaptive immune response, with particular emphasis on the search for potential T lymphocyte autoantigens. These investigations have been, in many cases, unrewarding. One reason may be that T cells are not the key players in self-nonself discrimination: T cell receptors (TCR) have randomly generated specificities that, for this reason, cannot determine the origin and biological context of their ligands [1]. It is becoming increasingly evident that this task is better carried out by the innate immune system that relies on germline-encoded receptors which bind to invariant molecules shared by large groups of microorganisms. These structures (techoic acids, lipopolysaccharides (LPS), double-stranded RNA, mannans) are therefore readily recognized as markers of infection by the innate immune system that instructs the adaptive response accordingly [2]. Based on this evidence, it is now clear that the correct functioning of innate and adaptive immunity as well as their balanced interaction are essential for a physiological immune response [3]. This has prompted much of the recent research focused on the interface between these two arms of the immune system in autoimmunity.

Keywords

Multiple Sclerosis Innate Immune System Multiple Sclerosis Plaque Extracellular Matrix Glycoprotein Cell Mediate Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia, Milan 1999

Authors and Affiliations

  • G. Ristori
  • A. Perna
  • C. Montesperelli
  • L. Battistini
  • R. Bomprezzi
  • S. Cannoni
  • G. Borsellino
  • C. Pozzilli
  • C. Buttinelli
  • M. Salvetti

There are no affiliations available

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