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The naïve and memory MBP-reactive CD4+ T cell repertoire: implications for the autoimmune concept in multiple sclerosis

  • P. A. Muraro
  • B. Bielekova
Conference paper

Abstract

T cells reacting to self-antigens may be involved in the pathogenesis of human autoimmune diseases, such as multiple sclerosis (MS). The pathogenesis of MS is currently ascribed, at least in part, to a T cell-mediated process targeting myelin components [1].Among myelin proteins, myelin basic protein (MBP) is a major candidate autoantigen in MS. The evidence supporting this claim has been examined in several excellent reviews [1–4], and includes the following well established observations: (1) degradation products of MBP are present in macrophages surrounding MS lesions; (2) MBP content in plaques is reduced; (3) the protein is relatively abundant (~30%) in central nervous system (CNS) myelin and (4) the immunodominant T cell epitope clusters of MBP [N-terminal (1–11, 1–19), central (87–106, 83–99, 87–99, 84–102), central (111–129, 115–125), C-terminal (143–168, 131–159)] are predominantly recognized in the context of MS-associated HLA-DR molecules [5–10].

Keywords

Multiple Sclerosis Myelin Basic Protein Experimental Allergic Encephalomyelitis Cell Repertoire naIve Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia, Milan 1999

Authors and Affiliations

  • P. A. Muraro
  • B. Bielekova

There are no affiliations available

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