The naïve and memory MBP-reactive CD4+ T cell repertoire: implications for the autoimmune concept in multiple sclerosis
T cells reacting to self-antigens may be involved in the pathogenesis of human autoimmune diseases, such as multiple sclerosis (MS). The pathogenesis of MS is currently ascribed, at least in part, to a T cell-mediated process targeting myelin components .Among myelin proteins, myelin basic protein (MBP) is a major candidate autoantigen in MS. The evidence supporting this claim has been examined in several excellent reviews [1–4], and includes the following well established observations: (1) degradation products of MBP are present in macrophages surrounding MS lesions; (2) MBP content in plaques is reduced; (3) the protein is relatively abundant (~30%) in central nervous system (CNS) myelin and (4) the immunodominant T cell epitope clusters of MBP [N-terminal (1–11, 1–19), central (87–106, 83–99, 87–99, 84–102), central (111–129, 115–125), C-terminal (143–168, 131–159)] are predominantly recognized in the context of MS-associated HLA-DR molecules [5–10].
KeywordsMultiple Sclerosis Myelin Basic Protein Experimental Allergic Encephalomyelitis Cell Repertoire naIve Cell
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