Skip to main content
Book cover

Advances in the Immunopathogenesis of Multiple Sclerosis pp 79–84Cite as

Experimental autoimmune encephalomyelitis in the common marmoset Callithrix jacchus

  • Conference paper

  • 62 Accesses

Abstract

Experimental autoimmune encephalomyelitis (EAE) has been utilized since the first studies of Rivers et al. [1] as the animal model of choice for autoimmune diseases and in particular demyelinating disease of the central nervous system (CNS) such as multiple sclerosis (MS). EAE is characterized by an autoimmune response against myelin antigens mediated mostly by T lymphocytes but also by macrophages and B cells [2]. Activated CD4+ T cells mediate EAE upon recognition of the target antigen presented by class II molecules of the major histocompatibility complex (MHC) [3]. EAE can be induced in susceptible species by means of active immunization with CNS proteins and by passive transfer of encephalitogenic T cells to syngeneic recipients. Encephalitogenic T cells recognize myelin antigens and can be retrieved from the blood of both immunized and naive animals [4].

Keywords

  • Multiple Sclerosis
  • Experimental Autoimmune Encephalomyelitis
  • Myelin Basic Protein
  • Common Marmoset
  • Myelin Antigen

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-88-470-2269-0_10
  • Chapter length: 6 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   84.99
Price excludes VAT (USA)
  • ISBN: 978-88-470-2269-0
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   109.00
Price excludes VAT (USA)
Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Rivers TM, Sprunt DH, Berry GP (1933) Observations on the attempts to produce acute-disseminated encephalomyelitis in monkeys. J Exp Med 58: 39–53

    PubMed  CrossRef  CAS  Google Scholar 

  2. Lassmann H, Wekerle H (1998) Experimental models of multiple sclerosis. In: Compston A, Ebers G, Lassmann H, McDonald I, Matthews B, Wekerle H (eds) McAlpine’s multiple sclerosis. Churchill Livingstone, London Edinburgh New York, pp 409–433

    Google Scholar 

  3. Zamvil SS, Steinman L (1990) The T lymphocyte in experimental allergic encephalomyelitis. Annu Rev Immunol 8: 579–621

    PubMed  CrossRef  CAS  Google Scholar 

  4. Genain CP, Lee-Parritz D, Nguyen MH, Massacesi L, Joshi N, Ferrante R, Hoffman K, Moseley M, Letvin NL, Hauser SL (1994) In healthy primates, circulating autoreactive T cells mediate autoimmune disease. J Clin Invest 94: 1339–1345

    PubMed  CrossRef  CAS  Google Scholar 

  5. Bontrop RE, Otting N, Slierendregt BL, Lanchbury JS (1995) Evolution of major histocompatibility complex polymorphisms and T cell receptor diversity in primates. Immunol Rev 143: 43–62

    CrossRef  Google Scholar 

  6. Massacesi L, Genain CP, Lee-Parritz D Letvin NL, Canfield D, Hauser SL (1995) Chronic relapsing experimental autoimmune encephalomyelitis in new world primates. Ann Neurol 37: 519–530

    CAS  Google Scholar 

  7. Uccelli A, Oksenberg JR, Jeong M, Genain CP, Rombos T, Jaeger E, Lanchbury J, Hauser SL (1997) Characterization of the TCRB chain repertoire in the New World monkey Callithrix jacchus. J Immunol 158: 12011207

    Google Scholar 

  8. Antunes SG, de Groot NG, Brok H, Doxiadis G, Menezes AA, Otting N, Bontrop RE (1998) The common marmoset: a new world primate species with limited MHC class II variability. Proc Natl Acad Sci U S A 95: 11745–11750

    PubMed  CrossRef  CAS  Google Scholar 

  9. Genain CP, Nguyen MH, Letvin NL, Pearl R, Davis RL, Adelman L, Lees MB, Linington C, Hauser SL (1995) Antibody facilitation of multiple sclerosis-like lesions in a non-human primate. J Clin Invest 96: 2966–2974

    PubMed  CrossRef  CAS  Google Scholar 

  10. t Hart BA, Bauer J, Muller HJ, Melchers B, Nicolay K, Brok H, Bontrop RE, Lassmann H, Massacesi L (1998) Histopathological characterization of magnetic resonance imaging-detectable brain white matter lesions in a primate model of multiple sclerosis: a correlative study in the experimental autoimmune encephalomyelitis model in common marmosets ( Callithrix jacchus). Am J Pathol 153: 649–663

    Google Scholar 

  11. Genain CP, Cannella B, Hauser SL, Raine CS (1999) Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med 5: 170–175

    PubMed  CrossRef  CAS  Google Scholar 

  12. McFarland HI, Lobito AA, Johnson MM, Nyswaner JT, Frank JA, Palardy GR, Tresser N, Genain CP, Mueller JP, Matis LA, Lenardo MJ (1999) Determinant spreading associated with demyelination in a nonhuman primate model of multiple sclerosis. J Immunol 162: 2384–2390

    PubMed  CAS  Google Scholar 

  13. Laman JD, van Meurs M, Schellekens MM, de Boer M, Melchers B, Massacesi L, Lassmann H, Claassen E, ‘t Hart BA (1998) Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys ( Callithrix jacchus ). J Neuroimmunol 86: 30–45

    Google Scholar 

  14. Genain CP, Roberts T, Davis R, Nguyen M, Uccelli A, Faulds D, Hoffman K, Timmel G, Li Y, Ferrante R, Joshi N, Hedgpeth J, Hauser SL (1995) Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor. Proc Natl Acad Sci USA 92: 3601–3605

    PubMed  CrossRef  CAS  Google Scholar 

  15. Genain CP, Abel K, Belmar N, Villinger F, Rosenberg DP, Linington C, Raine CS, Hauser SL (1996) Late complications of immune deviation therapy in a nonhuman primate. Science 274: 2054–2057

    PubMed  CrossRef  CAS  Google Scholar 

Download references

Authors
  1. A. Uccelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. L. Mancardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Giunti
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Brok
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. Roccatagliata
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. Capello
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. B. t’Hart
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Oncology and Neuroscience, Medical School, University G. D’Annunzio, Chieti, Italy

    D. Gambi, P. A. Muraro & A. Lugaresi,  & 

  2. Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA

    P. A. Muraro

Rights and permissions

Reprints and Permissions

Copyright information

© 1999 Springer-Verlag Italia, Milan

About this paper

Cite this paper

Uccelli, A. et al. (1999). Experimental autoimmune encephalomyelitis in the common marmoset Callithrix jacchus . In: Gambi, D., Muraro, P.A., Lugaresi, A., Ecari, U. (eds) Advances in the Immunopathogenesis of Multiple Sclerosis. Springer, Milano. https://doi.org/10.1007/978-88-470-2269-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-2269-0_10

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0067-4

  • Online ISBN: 978-88-470-2269-0

  • eBook Packages: Springer Book Archive