Abstract
Experimental autoimmune encephalomyelitis (EAE) has been utilized since the first studies of Rivers et al. [1] as the animal model of choice for autoimmune diseases and in particular demyelinating disease of the central nervous system (CNS) such as multiple sclerosis (MS). EAE is characterized by an autoimmune response against myelin antigens mediated mostly by T lymphocytes but also by macrophages and B cells [2]. Activated CD4+ T cells mediate EAE upon recognition of the target antigen presented by class II molecules of the major histocompatibility complex (MHC) [3]. EAE can be induced in susceptible species by means of active immunization with CNS proteins and by passive transfer of encephalitogenic T cells to syngeneic recipients. Encephalitogenic T cells recognize myelin antigens and can be retrieved from the blood of both immunized and naive animals [4].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Rivers TM, Sprunt DH, Berry GP (1933) Observations on the attempts to produce acute-disseminated encephalomyelitis in monkeys. J Exp Med 58: 39–53
Lassmann H, Wekerle H (1998) Experimental models of multiple sclerosis. In: Compston A, Ebers G, Lassmann H, McDonald I, Matthews B, Wekerle H (eds) McAlpine’s multiple sclerosis. Churchill Livingstone, London Edinburgh New York, pp 409–433
Zamvil SS, Steinman L (1990) The T lymphocyte in experimental allergic encephalomyelitis. Annu Rev Immunol 8: 579–621
Genain CP, Lee-Parritz D, Nguyen MH, Massacesi L, Joshi N, Ferrante R, Hoffman K, Moseley M, Letvin NL, Hauser SL (1994) In healthy primates, circulating autoreactive T cells mediate autoimmune disease. J Clin Invest 94: 1339–1345
Bontrop RE, Otting N, Slierendregt BL, Lanchbury JS (1995) Evolution of major histocompatibility complex polymorphisms and T cell receptor diversity in primates. Immunol Rev 143: 43–62
Massacesi L, Genain CP, Lee-Parritz D Letvin NL, Canfield D, Hauser SL (1995) Chronic relapsing experimental autoimmune encephalomyelitis in new world primates. Ann Neurol 37: 519–530
Uccelli A, Oksenberg JR, Jeong M, Genain CP, Rombos T, Jaeger E, Lanchbury J, Hauser SL (1997) Characterization of the TCRB chain repertoire in the New World monkey Callithrix jacchus. J Immunol 158: 12011207
Antunes SG, de Groot NG, Brok H, Doxiadis G, Menezes AA, Otting N, Bontrop RE (1998) The common marmoset: a new world primate species with limited MHC class II variability. Proc Natl Acad Sci U S A 95: 11745–11750
Genain CP, Nguyen MH, Letvin NL, Pearl R, Davis RL, Adelman L, Lees MB, Linington C, Hauser SL (1995) Antibody facilitation of multiple sclerosis-like lesions in a non-human primate. J Clin Invest 96: 2966–2974
t Hart BA, Bauer J, Muller HJ, Melchers B, Nicolay K, Brok H, Bontrop RE, Lassmann H, Massacesi L (1998) Histopathological characterization of magnetic resonance imaging-detectable brain white matter lesions in a primate model of multiple sclerosis: a correlative study in the experimental autoimmune encephalomyelitis model in common marmosets ( Callithrix jacchus). Am J Pathol 153: 649–663
Genain CP, Cannella B, Hauser SL, Raine CS (1999) Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med 5: 170–175
McFarland HI, Lobito AA, Johnson MM, Nyswaner JT, Frank JA, Palardy GR, Tresser N, Genain CP, Mueller JP, Matis LA, Lenardo MJ (1999) Determinant spreading associated with demyelination in a nonhuman primate model of multiple sclerosis. J Immunol 162: 2384–2390
Laman JD, van Meurs M, Schellekens MM, de Boer M, Melchers B, Massacesi L, Lassmann H, Claassen E, ‘t Hart BA (1998) Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys ( Callithrix jacchus ). J Neuroimmunol 86: 30–45
Genain CP, Roberts T, Davis R, Nguyen M, Uccelli A, Faulds D, Hoffman K, Timmel G, Li Y, Ferrante R, Joshi N, Hedgpeth J, Hauser SL (1995) Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor. Proc Natl Acad Sci USA 92: 3601–3605
Genain CP, Abel K, Belmar N, Villinger F, Rosenberg DP, Linington C, Raine CS, Hauser SL (1996) Late complications of immune deviation therapy in a nonhuman primate. Science 274: 2054–2057
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer-Verlag Italia, Milan
About this paper
Cite this paper
Uccelli, A. et al. (1999). Experimental autoimmune encephalomyelitis in the common marmoset Callithrix jacchus . In: Gambi, D., Muraro, P.A., Lugaresi, A., Ecari, U. (eds) Advances in the Immunopathogenesis of Multiple Sclerosis. Springer, Milano. https://doi.org/10.1007/978-88-470-2269-0_10
Download citation
DOI: https://doi.org/10.1007/978-88-470-2269-0_10
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0067-4
Online ISBN: 978-88-470-2269-0
eBook Packages: Springer Book Archive