Abstract
Experimental autoimmune encephalomyelitis (EAE) has been utilized since the first studies of Rivers et al. [1] as the animal model of choice for autoimmune diseases and in particular demyelinating disease of the central nervous system (CNS) such as multiple sclerosis (MS). EAE is characterized by an autoimmune response against myelin antigens mediated mostly by T lymphocytes but also by macrophages and B cells [2]. Activated CD4+ T cells mediate EAE upon recognition of the target antigen presented by class II molecules of the major histocompatibility complex (MHC) [3]. EAE can be induced in susceptible species by means of active immunization with CNS proteins and by passive transfer of encephalitogenic T cells to syngeneic recipients. Encephalitogenic T cells recognize myelin antigens and can be retrieved from the blood of both immunized and naive animals [4].
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© 1999 Springer-Verlag Italia, Milan
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Uccelli, A. et al. (1999). Experimental autoimmune encephalomyelitis in the common marmoset Callithrix jacchus . In: Gambi, D., Muraro, P.A., Lugaresi, A., Ecari, U. (eds) Advances in the Immunopathogenesis of Multiple Sclerosis. Springer, Milano. https://doi.org/10.1007/978-88-470-2269-0_10
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DOI: https://doi.org/10.1007/978-88-470-2269-0_10
Publisher Name: Springer, Milano
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