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Experimental autoimmune encephalomyelitis in the common marmoset Callithrix jacchus

  • A. Uccelli
  • G. L. Mancardi
  • D. Giunti
  • H. Brok
  • L. Roccatagliata
  • E. Capello
  • B. t’Hart
Conference paper

Abstract

Experimental autoimmune encephalomyelitis (EAE) has been utilized since the first studies of Rivers et al. [1] as the animal model of choice for autoimmune diseases and in particular demyelinating disease of the central nervous system (CNS) such as multiple sclerosis (MS). EAE is characterized by an autoimmune response against myelin antigens mediated mostly by T lymphocytes but also by macrophages and B cells [2]. Activated CD4+ T cells mediate EAE upon recognition of the target antigen presented by class II molecules of the major histocompatibility complex (MHC) [3]. EAE can be induced in susceptible species by means of active immunization with CNS proteins and by passive transfer of encephalitogenic T cells to syngeneic recipients. Encephalitogenic T cells recognize myelin antigens and can be retrieved from the blood of both immunized and naive animals [4].

Keywords

Multiple Sclerosis Experimental Autoimmune Encephalomyelitis Myelin Basic Protein Common Marmoset Myelin Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia, Milan 1999

Authors and Affiliations

  • A. Uccelli
  • G. L. Mancardi
  • D. Giunti
  • H. Brok
  • L. Roccatagliata
  • E. Capello
  • B. t’Hart

There are no affiliations available

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