History, Epidemiology and Clinical Evaluation of Rheumatoid Arthritis

  • Giacomo Garlaschi
  • Enzo Silvestri
  • Luigi Satragno
  • Marco Amedeo Cimmino


Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease of the joints that affects subjects of all ages, with a predilection for women of post­menopausal age. Although the etiology of RA is still unknown, its pathogenesis is the result of multiple factors acting against the background of genetic predisposi­tion. Inflammation is probably triggered by nonspecific and as yet unknown infec­tious agents. The course of RA is usually chronic with alternating periods of exac­erbation and abatement. RA is not necessarily confined to the joints but can cause extraarticular manifestations that are frequently severe and sometimes life-threat­ening.


Rheumatoid Arthritis Rheumatoid Arthritis Patient Bronchiolitis Obliterans Extra Articular Manifestation American Rheumatism Association 
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Copyright information

© Springer-Verlag Italia, Milano 2002

Authors and Affiliations

  • Giacomo Garlaschi
    • 1
  • Enzo Silvestri
    • 1
  • Luigi Satragno
    • 2
  • Marco Amedeo Cimmino
    • 3
  1. 1.Department of Experimental MedicineUniversity of GenoaItaly
  2. 2.MRI DivisionEsaote GroupGenoaItaly
  3. 3.Department of Internal Medicine, Division of RheumatologyUniversity of GenoaItaly

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