Endocrinological Changes and Asthma

  • G. Piatti
  • S. Centanni


It is well known that the pathogenesis of bronchial asthma is multifactorial. However, fluctuations in sex hormones can also modulate bronchomotor tone, although there is not always agreement on hormonal effects on the airways and in vitro results often conflict with in vivo observations.


Menstrual Cycle Bronchial Smooth Muscle Peak Flow Measurement Plasma Free Cortisol Endocrinological Change 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Valerio G, Lella A, Fanizza G, Barbanente P, Atimonelli R, Carnimeo N (1987) Airway hyperreactivity and menstrual cycle in asthmatic patients. Allergol Immunopathol (Madr) 15 (6): 379–381Google Scholar
  2. 2.
    Bonner JR (1983) The epidemiology and natural history of asthma. Clin Chest Med 5: 557–565Google Scholar
  3. 3.
    Falliers, CJ (1981) Developmental and endocrine aspects of respiratory allergy. J Asthma 18: 17–21PubMedCrossRefGoogle Scholar
  4. 4.
    Gibbs CJ, Coutts II, Lock R, Finnegan OC, White RJ (1984) Premenstrual exacerbation of asthma. Thorax 39: 833–836PubMedCrossRefGoogle Scholar
  5. 5.
    Stokes DN (1988) Premenstrual asthma (letter). Anaesthesia 43 (7): 601–602PubMedCrossRefGoogle Scholar
  6. 6.
    Eliasson O, Scherzer HH (1984) Recurrent respiratory failure in premenstrual asthma. Conn Med 48: 777–778PubMedGoogle Scholar
  7. 7.
    Eliasson O, DeGraff-Ac JR (1987) A cautionary tale about investigations of the effect of the menstrual cycle on asthma. Am Rev Respir Dis 136: 1515–1516PubMedCrossRefGoogle Scholar
  8. 8.
    Eliasson O, Scherzer HH, DeGraff-Ac JR (1986) Morbidity in asthma in relation to the menstrual cycle. J Allergy Clin Immunol 77 (1): 87–94PubMedCrossRefGoogle Scholar
  9. 9.
    Eliasson O, Longo M, Dore-Duffy P, Densmore MJ, DeGraff-Ac JR (1986) Serum 13–14 di OH-15-Keto-prostaglandin F2 alpha and airway response to meclofenamate and metaproterenol in relation to the menstrual cycle. J Asthma 23 (6): 309–319PubMedCrossRefGoogle Scholar
  10. 10.
    Dalton K (1988) Progesterone for premenstrual exacerbations of asthma (letter). Lancet 17 (2): 684CrossRefGoogle Scholar
  11. 11.
    Beynon HL, Garbett ND, Barnes PJ (1988) Severe premenstrual exacerbations of asthma: effect of intramuscular progesterone. Lancet 13 (2): 370–372CrossRefGoogle Scholar
  12. 12.
    Chen HI, Tang YR (1989) Effects on the menstrual cycle on respiratory muscle function. Am Rev Respir Dis 140: 1359–1362PubMedCrossRefGoogle Scholar
  13. 13.
    Juniper EF, Kline PA, Roberts RS, Hargreave FE, Daniel EE (1987) Airway responsiveness to metacholine during the natural menstrual cycle and the effect to oral contraceptives. Am Rev Respir Dis 135: 1039–1042PubMedGoogle Scholar
  14. 14.
    Foster PS, Goldie RG, Paterson JW (1983) Effect of steroids on beta-adrenoceptor-mediated relaxation of pig bronchus. Br J Pharmacol 78: 441–445PubMedGoogle Scholar
  15. 15.
    Eliasson O, Densmore MJ, Scherzer HH, DeGraff-Ac JR (1987) The effect of sodium meclofenamate in premenstrual asthma: a controlled clinical trial. J Allergy Clin Immunol 79: 909–918PubMedCrossRefGoogle Scholar
  16. 16.
    Lenoir RJ (1987) Severe acute asthma and the menstrual cycle. Anaesthesia 42: 1287–1290PubMedCrossRefGoogle Scholar
  17. 17.
    Pelikan Z (1978) Possible immediate hypersensitivity reaction of the nasal mucosa to oral contraceptives. Ann. Allergy 40: 211–219PubMedGoogle Scholar
  18. 18.
    Juniper EF, Daniel EE, Roberts RS, Kline PA, Hargreave FE, Hewhouse HT (1989) Improvement in airway responsiveness and asthma severity during pregnancy. A prospective study. Am Rev Respir Dis 140: 924–931Google Scholar
  19. 19.
    Cohendy R, Godard, P, Bousquet J, Aubas P, Michel FB (1988) Pregnancy and asthma. Rev Mal Respir 5 (3): 261–267PubMedGoogle Scholar
  20. 20.
    Huff RW (1989) Asthma in pregnancy. Med Clin North Am 73 (3): 653–660PubMedGoogle Scholar
  21. 21.
    Guerin JM, Meyer P, Habib Y (1987) Asthma during pregnancy. Rev Pneumol Clin 43 (3): 156–159PubMedGoogle Scholar
  22. 22.
    Gluck JC, Gluck PA (1976) The effects of pregnancy on asthma: a prospective study. Ann Allergy 37: 164–168PubMedGoogle Scholar
  23. 23.
    Di Marco AF (1989) Asthma in the pregnant patient: a review. Ann Allergy 62 (6): 527–533Google Scholar
  24. 24.
    Schatz M, Hoffman C (1987) Interrelationships between asthma and pregnancy: clinical and mechanistic considerations. Clin Rev Allergy 5 (4): 301–315PubMedGoogle Scholar
  25. 25.
    Weber RW, Nelson HS (1986) Immunologic and atopic aspects of pregnancy and lactation. Ann Allergy 57 (3): 159–166PubMedGoogle Scholar
  26. 26.
    Spector SL (1984) Reciprocal relationship between pregnancy and pulmonary disease. State of the art. Chest 86: 1S - 5SPubMedCrossRefGoogle Scholar
  27. 27.
    Greenberger PA (1985) Asthma in pregnancy. Clin Perinatol 12 (3): 571–584PubMedGoogle Scholar
  28. 28.
    Harman EM (1985) Pulmonary problems of pregnancy. Compr Ther 11 (5): 26–32PubMedGoogle Scholar
  29. 29.
    Schatz M, Harden K, Forsythe A, Chilingar L, Hoffman C, Sperling W (1988) The course of asthma during pregnancy post-partum and with successive pregnancies; a prospective analysis. J Allergy Clin Immunol 81 (3): 509–517PubMedCrossRefGoogle Scholar
  30. 30.
    Farina F, Colombi S, Cantone R, Pastore M, Centanni S, Galimberti M (1986) Studio degli ormoni ipofiso-gonadici in alcuni casi di asma bronchiale. Min Med 77: 243–247Google Scholar
  31. 31.
    Farina F, Francioni S, Galimberti M, Pastore M, Centanni S, Anomalie ormonali in un caso di asma bronchiale ad insorgenza perimenopausale. GIMT 37: 145–148Google Scholar
  32. 32.
    Garfield RE, Kannan MS, Daniel EE (1980) Gap-junction formation in myometrium: control by estrogens, progesterone and prostaglandins. Am J Physiol 238: C81–89PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • G. Piatti
    • 1
  • S. Centanni
    • 1
  1. 1.Institute of Respiratory Diseases, School of MedicineUniversity of MilanMilanoItaly

Personalised recommendations