Mediators in Bronchial Provocation Tests

  • N. Del Bono
  • L. Del Bono


Three major pathogenetic components characterize bronchial asthma: (1) atopy, i.e., increased levels of IgE and increased degranulation of mast cells and basophils triggered by IgE-mediated or non-IgE-mediated stimuli; (2) allergic inflammation, which damages to varying extents the bronchial wall components (epithelium, vessels, submucosal glands, respiratory nerve endings, and smooth muscle); (3) bronchial hyperreactivity (BH) to physical, chemical, and allergic stimuli, which trigger bronchial obstruction by bronchospasm, vasodilation, mucosal edema, and mucous hypersecretion.


Force Vital Capacity Allergy Clin Immunol Total Lung Capacity Asthmatic Subject Geometric Standard Deviation 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • N. Del Bono
    • 1
  • L. Del Bono
    • 1
  1. 1.Centro per lo Studio dell‘ Asma e delle Allergopatie RespiratoriePisaItaly

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