Skip to main content

Allergen Administration in Bronchial Provocation Tests

  • Chapter
Methods in Asthmology

Abstract

Allergen inhalation tests measure the respiratory response to inhaled allergen. The response can be localised to the airways, to the peripheral respiratory tissues or both. In this chapter we will deal only with airway (asthmatic) responses. The materials and methods described in this chapter are those used in our laboratory, however, the principles are generally applicable. Alternative methods are considered in the Discussion.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Altounyan REC (1970) Changes in histamine and atropine responsiveness as a guide to diagnosis and evaluation of therapy in obstructive airways disease. In: Pepys J, Frandland AW (eds) Disodium cromoglycate in allergic airways disease. Butterworth, London, pp 47–53

    Google Scholar 

  2. Bryant DH, Burns MW (1976) Bronchial histamine reactivity: its relationship to reactivity of the bronchi to allergens. Clin Allergy 6: 523–532.

    Article  PubMed  CAS  Google Scholar 

  3. Cartier A, Thomson NC, Frith PA, Roberts R, Hargreave FE (1982) Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late 180 B. J. O. Wong and F. E. Hargreave asthmatic response and change in airway caliber. J Allergy Clin Immunol 70: 170–177

    Google Scholar 

  4. Chai H, Farr RS, Froehlich LA, Mathison DA, McLean JA, Rosenthal RR, Sheffer AL, Spector SI, Townley RG (1975) Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol 56: 323–327

    Article  PubMed  CAS  Google Scholar 

  5. Cockcroft DW, Killian DN, Mellon JJA, Hargreave FE (1977) Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy 7: 235–243

    Article  PubMed  CAS  Google Scholar 

  6. Cockcroft DW, Ruffin RE, Dolovich J, Hargreave FE (1977) Allergen-induced increase in non-allergic bronchial reactivity. Clin Allergy 7: 503–513

    Article  PubMed  CAS  Google Scholar 

  7. Cockcroft DW, Murdock KY (1987) Changes in bronchial responsiveness to histamine at intervals after allergen challenge. Thorax 42: 302–308

    Article  PubMed  CAS  Google Scholar 

  8. Cockcroft DW, Murdock KY, Kirby J, Hargreave F (1987) Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine. Am Rev Respir Dis 135: 264–267

    PubMed  CAS  Google Scholar 

  9. Crimi E, Brusasco V, Losurdo E, Crimi P (1986) Predictive accuracy of late asthmatic reaction to dermatophagoides pteronyssinus. J Allergy Clin Immunol 78: 908–913

    Article  PubMed  CAS  Google Scholar 

  10. Durham SR, Craddock CF, Cookson WO, Benson MK (1988) Increases in airway responsiveness to histamine precede allergen-induced late asthmatic responses. J Allergy Clin Immunol 82: 764–770

    Article  PubMed  CAS  Google Scholar 

  11. Frith PA, Ruffin RE, Juniper EF, Dolovich J, Hargreave FE (1981) Inhibition of allergen-induced asthma by three forms of sodium cromoglycate. Clin Allergy 11: 67–77

    Article  PubMed  CAS  Google Scholar 

  12. Gibson PG, Manning PJ, O’Byrne PM, Girgis-Gabardo A, Dolovich J, Denburg JA, Hargreave FE (1991) Allergen induced asthmatic responses: relationship between increases in airway responsiveness and increases in circulating eosinophils, basophils and their progenitors. Am Rev Respir Dis 1991; 143: 331–335

    Google Scholar 

  13. Hargreave FE (1987) Inhalation provocation tests. In: Lessof MH, Lee TH, Kemeny DM (eds) Allergy: an international textbook. Wiley, Chichester, pp 289–303

    Google Scholar 

  14. Hargreave FE, Dolovich J, Robertson DG, Kerigan AT (1974) II. The late asthmatic responses. Can Med Assoc J 110: 415–424

    Google Scholar 

  15. Hargreave FE, Fink JN, Cockcroft DW, Fish JE, Holgate ST, Ramsdale EH, Roberts RS, Shapiro GG, Sheppard D (1986) Workshop 4: the role of bronchoprovocation. J Allergy Clin Immunol 78: 517–524

    Article  Google Scholar 

  16. Hargreave FE, Marone G, Platts-Mills T (1989) Diagnostic procedures. In: Hol-gate ST (ed) The role of inflammatory processes in airway hyperresponsiveness. Blackwell, Oxford, pp 80–107

    Google Scholar 

  17. Herxheimer H (1952) The late bronchial reaction in induced asthma. Int Arch Allergy 3: 323–328

    Article  PubMed  CAS  Google Scholar 

  18. Hoeppner VH, Murdock KY, Kooner S, Cockcroft DW (1985) Severe acute occupational asthma: caused by accidental allergen exposure in an allergen challenge laboratory. Ann Allergy 55 (1): 36–37

    PubMed  CAS  Google Scholar 

  19. Juniper EF, Frith PA, Hargreave FE (1981) Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma. Thorax 36: 575–579

    Article  PubMed  CAS  Google Scholar 

  20. Juniper EF, Kline PA, Vanzieleghem MA, Ramsdale EH, O’Byrne PM, Hargreave FE (1990) Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in nonsteroiddependent asthmatics. Am Rev Respir Dis 142: 832–836

    PubMed  CAS  Google Scholar 

  21. Juniper EF, Cockcroft DW, Hargreave FE (1991) Histamine and methacholine inhalation tests: a laboratory tidal breathing protocol. AB DRACO (subsidiary of ABASTRA) Lund, Sweden 1991

    Google Scholar 

  22. Lai CKW, Twentyman OP, Holgate ST (1989) The effect of an increase in inhaled allergen dose after rimiterol hydrobromide on the occurrence and magnitude of the late asthmatic response and associated change in nonspecific bronchial responsiveness. Am Rev Respir Dis 140: 917–923

    PubMed  CAS  Google Scholar 

  23. Lowenstein H (1983) Report on behalf of the International Union Standardization Subcommittee. Arb Paul Ehrlich Inst 78: 41–48

    PubMed  Google Scholar 

  24. Lowenstein H, Ipsen H, Lind P, Matthiesen F (1987) The physicochemical and biological characteristics of allergens. In: Lessof MH, Lee TH, Kemeny DM (eds) Allergy: an international textbook. Wiley, Chichester, pp 87–104

    Google Scholar 

  25. Machado L, Stalenheim G (1990) Factors influencing the occurrence of late bronchial reactions after allergen challenge. Allergy 45 (4): 268–274

    Article  PubMed  CAS  Google Scholar 

  26. Melillo G (1986) Bronchial Challenge with a micronized, freeze-dried allergen extract administered as a powder by a special turboinhaler. In: Melillo G, Cocco G, Centanni G (eds) XIIIth congress on of the European academy of allergology and clinical immunology — workshop on “The use of allergen in powder form for provocation tests and for immunotherapy in allergic asthma”, pp 3–14

    Google Scholar 

  27. O’Byrne PM, Dolovich J, Hargreave FE (1987) Late asthmatic responses. Am Rev Respir Dis 136: 740–751

    Article  PubMed  Google Scholar 

  28. Pepys J, Hargreave FE, Chan M, McCarthy DS (1968) Inhibitory effects of dis-odium cromoglycate ( Intal) on allergen inhalation tests. Lancet ii: 134

    Google Scholar 

  29. Ruffin RE, Cockcroft DW, Hargreave FE (1978) A comparison of the protective effect of fenoterol and Sch1000 on allergen-induced asthma. J Allergy Clin Immunol 61:42— 47

    Google Scholar 

  30. Ryan G, Latimer KM, Dolovich J, Hargreave FE (1982) Bronchial responsiveness to histamine: relationship to diurnal variation of peak flow rate, improvement after bronchodilator and airway calibre. Thorax 37: 423–429

    Article  PubMed  CAS  Google Scholar 

  31. Woolcock AJ, Yan K, Salome CM (1988) Effect of therapy on bronchial hyper-responsiveness in the long-term management of asthma. Clin Allergy 18: 165–176

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Wong, B.J.O., Hargreave, F.E. (1993). Allergen Administration in Bronchial Provocation Tests. In: Allegra, L., Braga, P.C., Dal Negro, R. (eds) Methods in Asthmology. Springer, Milano. https://doi.org/10.1007/978-88-470-2263-8_10

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-2263-8_10

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2265-2

  • Online ISBN: 978-88-470-2263-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics