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Naloxone, but not Estradiol, Affects the Gonadectomy-Induced Increase in Hippocampal Cholineacetyltransferase Activity in Male Rats

  • I. Ceccarelli
  • A. Scaramuzzino
  • A. M. Aloisi
Conference paper
Part of the Topics in Anaesthesia and Critical Care book series (TIACC)

Abstract

Cholinergic neurons located in the medial septum and the diagonal band of Broca are a major source of cholinergic innervation to the hippocampal formation. These neurons play an important role in learning and memory processes [1]. Gonadal hormones can significantly affect the function of these cholinergic neurons [2]. Estrogens were found to increase cholineacetyltransferase (ChAT) activity and the number of ChAT neurons in the medial septum in ovariectomized female rats [3]. Moreover, estrogens significantly improve cognition capacities in menopausal women treated with estrogen-replacement therapy [4]. Although not a limiting factor in the synthesis of ACh, ChAT activity is considered an index of cholinergic activation [5]. We have previously shown that a persistent, painful stimulus (for-malin test) decreases ChAT activity in male rats, an effect not present in females [6], and induces higher c-Fos expression levels in the hippocampus of female rats than in males [7].

Keywords

Cholinergic Neuron Choline Acetyltransferase Formalin Test Gonadal Hormone Medial Septum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia, Milano 2001

Authors and Affiliations

  • I. Ceccarelli
  • A. Scaramuzzino
  • A. M. Aloisi

There are no affiliations available

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