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Part of the book series: Topics in Anaesthesia and Critical Care ((TIACC))

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Abstract

Sensory neurons responding to stimuli capable of producing tissue damage are termed nociceptors and have free nerve endings of either myelinated small-diameter (Aδ) or unmyerlinated (C) fiber axons. They display either single or multiple receptive fields. Nociceptive afferents supply skin, subcutaneous tissue, periosteum, joints, muscles and viscera. Nociceptors also innervate vessels, meninges, and nervi nervorum.Skin, subcutaneous tissue and fascia are supplied by mechanical nociceptor afferents and heat and cold nociceptors; most of Aδ and C nociceptors in primates are mechano-heat sensitive and respond to chemical stimuli as well and are referred to as polymodal nociceptors.

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References

  1. Treede RD, Meyer RA, Raja SN, Campbell JN (1995) Evidence for two different transduction mechanisms in nociceptive primary afferents innervating monkey skin. J Physiol 483: 747–758

    CAS  PubMed  Google Scholar 

  2. Campbell JN, LaMotte RH (1983) Latency to detection of first pain. Brain Res 266: 203–208

    Article  Google Scholar 

  3. Simone DA, Kajander KC (1997) Responses of cutaneous A-fiber nociceptors to noxious cold. J Neurophysiol 77: 2049–2060.

    CAS  PubMed  Google Scholar 

  4. Harrison JLK, Davis KD (1999) Cold evoked pain varies with skin type and cooling rate: a psychophysical study in humans. Pain 83: 123–135

    Article  CAS  PubMed  Google Scholar 

  5. Steen KH, Reeh P, Anton F, Handwerker HO (1992) Protons selectively induce long lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro. J Neurosci 12: 86–95

    CAS  PubMed  Google Scholar 

  6. Caterina JM, Schumacher MA, Tominaga M, et al (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389: 816–824

    Article  CAS  PubMed  Google Scholar 

  7. Reeh PW, Petho G (2000) Nociceptor excitation by thermal sensitization-a hypothesis. In: Sandkuler J, Gebart GF, Bromm B (eds) Nervous System Plasticity and Chronic Pain. Progress in Brain Research Elsevier, Amsterdam (in press)

    Google Scholar 

  8. Herz A (1996) Peripheral opioid analgesia-facts and mechanisms. In: Carli G, Zimmermann M (eds) Towards the Neurobiology of Chronic Pain. Progress in Brain Research, vol 110. Elsevier, Amsterdam, pp 95–110

    Chapter  Google Scholar 

  9. Schmeltz M, Schmidt R, Ringkamp M, et al (1994) Sensitization of insensitive branches of C nociceptors in human skin. J Physiol 480: 389–394

    Google Scholar 

  10. Michaelis M, Habler H-G, Janig W (1997) Silent afferent neurons:a separate class of primary afferents? Clin Exp Pharmacol Physiol 23: 99–105

    Article  Google Scholar 

  11. Adriaensen H, Gybels J, Handwerker HO, Van Hees J (1984) Nociceptor discharges and sensation due to prolonged noxious mechanical stimulation-a paradox. Hum Neurobiol 3: 53–58

    CAS  PubMed  Google Scholar 

  12. White DM, Taiwo YO, Coderre TJ, Levine JD (1991) Delayed activation of nociceptors:correlation with delayed pain sensations induced by sustained stimuli. J Neurophysiol 66: 229–234

    Google Scholar 

  13. Liu C-N, Wall PD, Ben-Dor E, et al (2000) Tactile allodynia in the absence of C-fiber activation:altered firing properties of DRG neurons following spinal nerve injury. Pain 85: 503–521

    Article  CAS  PubMed  Google Scholar 

  14. Li Y, Dorsi MJ, Meyer RA, and Belzberg AJ (2000) Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers. Pain 85: 493–502

    Article  CAS  PubMed  Google Scholar 

  15. Koltzenburg GM, Wall PD, McMahon SB (1999) Does the right side know what the left is doing?. Trends Neurosci 22: 122–127

    Article  CAS  PubMed  Google Scholar 

  16. Sato J, Perl ER (1991) Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science 251: 1608–1610

    Article  CAS  PubMed  Google Scholar 

  17. Devor M, Seltzer Z (1999) Pathophysiology of damaged nerves in relation to chronic pain. In: Wall PD, Melzack R (eds) Textbook of pain. Churchill Livingston, London, pp 129–164

    Google Scholar 

  18. Bossut DF, Shea VK, Perl ER (1996) Sympathectomy induces adrenergic excitability of cutaneous C-Fiber nociceptors. J Neurophysiol 75: 514–517

    CAS  PubMed  Google Scholar 

  19. McMahon SB, Bennet DLH (1994) Trophic factors and pain. In: Wall PD, Melzack R (eds) Textbook of pain. Churchill-Livingston, Edinburgh, pp 105–128

    Google Scholar 

  20. Elliott JR (1997) Slow Na+ channel inactivation and bursting discharge in a simple model axon: implications for neuropathic pain. Brain Res 754: 221–226

    Article  CAS  PubMed  Google Scholar 

  21. Devor M, Govrin-Lippmann R, Angelides K (1993) Na+ channel immunolocalization in peripheral mammalian axons and changes following nerve injury and neuroma formation. J Neurosci 13: 1966–1992

    Google Scholar 

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© 2001 Springer-Verlag Italia, Milano

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Carli, G. (2001). First Affluent Neuron. In: Tiengo, M.A. (eds) Neuroscience: Focus on Acute and Chronic Pain. Topics in Anaesthesia and Critical Care. Springer, Milano. https://doi.org/10.1007/978-88-470-2258-4_3

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  • DOI: https://doi.org/10.1007/978-88-470-2258-4_3

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0134-3

  • Online ISBN: 978-88-470-2258-4

  • eBook Packages: Springer Book Archive

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