Neurochemistry of Pain Circuits: Physiological versus Pathological Pain

  • L. Calzà
Conference paper
Part of the Topics in Anaesthesia and Critical Care book series (TIACC)


In the last 15 years, human and animal studies have indicated that the anatomical, neurochemical and functional correlates of pain states are quite different in symptomatic and pathologic pain [1, 2]. Thus, the biological substrate for pharmacological therapy is different for treating acute, symptomatic pain and different types of pathologic chronic pain. Moreover, the pathophysiology of a long-lasting pain syndrome also changes with the course of a disease.


Nerve Growth Factor Dorsal Root Ganglion Neuropathic Pain Dorsal Horn Dorsal Root Ganglion Neuron 
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© Springer-Verlag Italia, Milano 2001

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  • L. Calzà

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