Abstract
The inflammatory bowel diseases (IBD), Crohn’s Disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the intestines with a combined prevalence of 200–300 per 100 000 persons in the industrialized world [1]. The peak frequency of new cases of CD in the pediatric population is during the mid to late teens with an age-specific incidence of 16 per 100 000 persons [2]. It was suggested that a threefold rise in the incidence of CD occurred between 1968 to 1983, which further increased to 4.4 fold between 1968 and 1988 [3]. In contrast, UC did not show an upward trend during the same period [3]. A positive family history is the most consistent risk factor for children with IBD (odds ratio 5.6) [4].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Calkins BM, Mendeloff AI (1986) Epidemiology of inflammatory bowel disease. Epidemiol Rev 8: 60–91
Haug K, Schrump EH, Halverson JF, et al. and the study group of IBD in western Norway (1989) Epidemiology of Crohn’s disease in western Norway. Scand J Gastroenterol 24: 1271
Barton RJ, Gillon S, Ferguson A (1989) Incidence of 1BD in Scottish children between 1968 and 1983, marginal fall in UC, three fold rise in CD. Gut 30: 618
Gilat T, Hacohen D, Lios P, et al. (1987) Childhood factors in UC and CD. An international cooperative study. Scand J Gastroenterol 22: 1009
Orholm M, Munkholm P, Langholz E, Nielsen OH, Sorensen TIA, Binder V (1991) Familial occurrence of inflammatory bowel disease. J Engl J Med 324: 84–88
Lander ES, Schork NJ (1994) Genetic dissection of complex traits. Science 265: 2037–2048
Satsangi J, Jewell DP, Bell JI (1997) The genetics of inflammatory bowel disease. Gut 40: 572–574
Hugot JP, Laurent-Puig P, Gower-Rousseau C, Olson JM, Le JC, et al. (1966) Mapping of a susceptibility locus for Crohn’s disease on chromosome 16. Nature 379: 821–823
Cho JH, Nicolae DL, Gold LH, et al. (1998) Identification of novel susceptibility loci for inflammatory bowel disease on chromosome 1 p, 3q and 4q: evidence for epitasis between 1 p and IBD1. Proc Natl Acad Sci 95: 7502–7507
Satsangi J, Parkes M, Louis E, et al. (1996) Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3,7 and 12. Nat Genet 14: 199–202
Podolsky DK (1991) Inflammatory bowel disease. N Engl J Med 325: 928–937; 1008–1009
Gryboski JD (1993) Ulcerative colitis in children 10 years or younger. J Pediatr Gastroenterol Nutr 17: 24–31
Michener WM, Whelan G, Greenstreet RL, et al. (1982) Comparison of the clinical features of CD and UC with onset in childhood or adolescence. Clev Clin J Med 49: 13–16
Kirschner SB (1996) Ulcerative colitis in children. Pediatr Clin North Amer 43: 235–254
Hyams JS (1996) Crohn’s disease in children. Pediatr Clin North Amer 43: 255–277
van Deventer SJ (1997) Tumor necrosis factor and Crohn’s disease. Gut 40: 443–448
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer-Verlag Italia, Milano
About this paper
Cite this paper
Lebenthal, A., Lebenthal, E. (1999). The Wide Spectrum of Inflammatory Bowel Disease in Children. In: Bar-Ziv, J., Horev, G., Kalifa, G. (eds) Highlights of Pediatric Radiology. Syllabus. Springer, Milano. https://doi.org/10.1007/978-88-470-2253-9_17
Download citation
DOI: https://doi.org/10.1007/978-88-470-2253-9_17
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0061-2
Online ISBN: 978-88-470-2253-9
eBook Packages: Springer Book Archive