Malignant Tumors of the Dia/metaphysis

  • D. Jaramillo
Conference paper
Part of the Syllabus book series (SYLLABUS)


There are two main types of skeletal malignancies in children: round cell tumors and tumors that arise from mesenchymal elements [1]. Round cell tumors infiltrate the marrow, whereas mesenchymal tumors arise in areas of active ossification of cartilage and deposition of new bone. Marrow-infiltrating tumors include metastatic neuroblastoma, Ewing sarcoma, lymphoma, and Langerhans cell histiocytosis. All round cell tumors follow the distribution of hematopoietic bone marrow and do not produce tumor matrix. They destroy bone and are thus radiographically lytic. They also, however, elicit periosteal bone deposition and reactive bone formation both of which can increase radiographic density. Tumors related to the formation of cartilage and bone include osteogenic sarcomas, and cartilaginous tumors. These tumors tend to occur in the vicinity of the fastest growing physes (distal femur, proximal tibia, proximal humerus), and produce characteristic tumor matrix.


Magn Reson Image Proximal Humerus Ewing Sarcoma Primitive Neuroectodermal Tumor Malignant Bone Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia, Milano 1999

Authors and Affiliations

  • D. Jaramillo
    • 1
  1. 1.Department of RadiologyChildren’s Hospital and Harvard Medical SchoolBostonUSA

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