Sepsis and MODS - What Is Wrong and What Is Right

  • A. Gullo
  • G. Berlot
Conference paper


Despite major advances in the knowledge of the pathophysiologic mechanisms responsible of the develoment of sepsis and its related consequences, namely Multiple Organ Dysfunction Syndrome (MODS) and Failure (MOF), the mortality rate of septic patients remains high. Although this can be attributed to a number of factors, including the underlying diseases, a more advanced age of the affected patients, the appearance of antibiotic-resistant bacterial strains, etc., nevertheless it is surprising and somewhat disappointing that the clinical applications of the basic researches carried results far below the expectations [1]. Then, it appears rather logical to wonder a) if the measures developed to contrast sepsis, MODS and MOF on the basis of these experimental results are effective and b) if the main indicator used to assess the effectiveness of these approaches (namely the survival at a predetermined interval of time) is fully appropriate.


Septic Shock Systemic Inflammatory Response Syndrome Septic Patient Multiple Organ Dysfunction Syndrome Platelet Activate Factor Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia, Milano 1999

Authors and Affiliations

  • A. Gullo
  • G. Berlot

There are no affiliations available

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