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Sepsis and MODS - What Is Wrong and What Is Right

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Book cover Sepsis and Organ Dysfunction

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Abstract

Despite major advances in the knowledge of the pathophysiologic mechanisms responsible of the develoment of sepsis and its related consequences, namely Multiple Organ Dysfunction Syndrome (MODS) and Failure (MOF), the mortality rate of septic patients remains high. Although this can be attributed to a number of factors, including the underlying diseases, a more advanced age of the affected patients, the appearance of antibiotic-resistant bacterial strains, etc., nevertheless it is surprising and somewhat disappointing that the clinical applications of the basic researches carried results far below the expectations [1]. Then, it appears rather logical to wonder a) if the measures developed to contrast sepsis, MODS and MOF on the basis of these experimental results are effective and b) if the main indicator used to assess the effectiveness of these approaches (namely the survival at a predetermined interval of time) is fully appropriate.

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Authors
  1. A. Gullo
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  2. G. Berlot
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Editor information

Editors and Affiliations

  1. Department of Surgery, Saint Louis University, Health Sciences Center, St. Louis, USA

    A. E. Baue M.D.

  2. Department of Anaesthesia, Intensive Care and Pain Therapy, University of Trieste, Cattinara Hospital, Trieste, Italy

    G. Berlot M.D.  & A. Gullo M.D.  & 

  3. Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium

    J.-L. Vincent M.D.

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© 1999 Springer-Verlag Italia, Milano

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Gullo, A., Berlot, G. (1999). Sepsis and MODS - What Is Wrong and What Is Right. In: Baue, A.E., Berlot, G., Gullo, A., Vincent, JL. (eds) Sepsis and Organ Dysfunction. Springer, Milano. https://doi.org/10.1007/978-88-470-2248-5_8

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  • DOI: https://doi.org/10.1007/978-88-470-2248-5_8

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0052-0

  • Online ISBN: 978-88-470-2248-5

  • eBook Packages: Springer Book Archive

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