Shall We Continue to Talk About (or Use) SIRS in the Twenty-first Century?
Sepsis is a frequent cause of death on our intensive care units (ICUs) and despite advances in our understanding of the processes involved and elucidation of the inflammatory cascade, we remain no closer to finding a cure. The terminology employed in discussing disease processes is often confusing and frequently inadequate, perhaps never more so than with regard to the septic patient. Many words and phrases have been, and are, used in an attempt to define and describe the septic patient, including “infection”, “bacteraemia”, “septicaemia”, “severe sepsis”, “sepsis syndrome” ,
KeywordsSeptic Shock Acute Pancreatitis Severe Sepsis Septic Patient Consensus Conference
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Balk RA, Bone RC (1989) The septic syndrome: Definition and clinical implications. Crit Care Clin 5:1–8PubMedGoogle Scholar
Vincent JL (1994) Sepsis and septic shock: Update on definitions. In: Reinhart K, Eyrich K, Sprung C (eds) Sepsis: Current perspectives in pathophysiology and therapy. Springer, Berlin Heidelberg New York, pp 3–15Google Scholar
Members of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864–874CrossRefGoogle Scholar
Rangel-Frausto MS, Pittet D, Costigan M et al (1995) The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA 273:117–123PubMedCrossRefGoogle Scholar
Salvo I, de Cian W, Musicco M et al (1995) The Italian SEPSIS study: Preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock. Intensive Care Med 21:S244–S249PubMedCrossRefGoogle Scholar
Pittet D, Rangel-Frausto S, Li N et al (1995) Systemic inflammatory response syndrome, sepsis, severe sepsis and septic shock: incidence, morbidities and outcomes in surgical patients. Intensive Care Med 21:302–309PubMedCrossRefGoogle Scholar
Jones GR, Lowes JA (1996) The systemic inflammatory response syndrome as a predictor of bacteremia and outcome from sepsis. QJM 89:515–522PubMedCrossRefGoogle Scholar
Vincent JL (1997) Dear SIRS, I’m sorry to say I don’t like you. Crit Care Med 25:372–374PubMedCrossRefGoogle Scholar
Vincent JL, Moreno R, Takala J et al (1996) The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. Intensive Care Med 22:707–710PubMedCrossRefGoogle Scholar
Vincent JL (1998) Sepsis: The search continues for effective immunomodulating strategies. Lancet 351:922–923PubMedGoogle Scholar
Vincent JL (1997) New therapies in sepsis. Chest 112:330S–338SPubMedCrossRefGoogle Scholar
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